Detailed view for EmuJ_000504900

Basic information

TDR Targets ID: 965940
Echinococcus multilocularis, sugar phosphate exchanger 3
Source Database / ID:  GeneDB

pI: 7.9999 | Length (AA): 480 | MW (Da): 52330 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 475 1pw4 (A) 27 451 25.00 0 0.44 1.03523 0.62
84 467 4c7r (A) 130 483 15.00 0 0.84 0.7831 0.31
284 455 4q65 (A) 22 186 17.00 0.00001 0.22 0.513333 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127818)

Species Accession Gene Product
Arabidopsis thaliana AT1G30560   putative glycerol-3-phosphate transporter 3
Arabidopsis thaliana AT4G25220   putative glycerol-3-phosphate transporter 2
Arabidopsis thaliana AT4G17550   glycerol-3-phosphate permease 4
Arabidopsis thaliana AT3G47420   putative glycerol-3-phosphate transporter 1
Babesia bovis BBOV_IV006000   conserved hypothetical protein
Brugia malayi Bm1_02245   hypothetical protein
Caenorhabditis elegans CELE_T11G6.4   Protein T11G6.4
Caenorhabditis elegans CELE_T10C6.6   Protein T10C6.6, isoform D
Caenorhabditis elegans CELE_T11G6.2   Protein T11G6.2, isoform B
Caenorhabditis elegans CELE_T11G6.3   Protein T11G6.3
Cryptosporidium hominis Chro.80188   hexosphosphate transport
Cryptosporidium parvum cgd8_1600   sugar phosphate permease with 11 transmembrane domains
Drosophila melanogaster Dmel_CG10069   Major Facilitator Superfamily Transporter 16
Echinococcus granulosus EgrG_000356200   sugar phosphate exchanger
Echinococcus granulosus EgrG_000504900   sugar phosphate exchanger 3
Echinococcus granulosus EgrG_001051500   Glycerol 3 phosphate transporter
Echinococcus multilocularis EmuJ_000504900   sugar phosphate exchanger 3
Echinococcus multilocularis EmuJ_001051500   Glycerol 3 phosphate transporter
Echinococcus multilocularis EmuJ_000356200   sugar phosphate exchanger solute carrier family
Homo sapiens ENSG00000157800   solute carrier family 37, member 3
Homo sapiens 219855   solute carrier family 37 (glucose-6-phosphate transporter), member 2
Homo sapiens ENSG00000160190   solute carrier family 37 (glucose-6-phosphate transporter), member 1
Loa Loa (eye worm) LOAG_11487   hypothetical protein
Mus musculus ENSMUSG00000029924   solute carrier family 37 (glycerol-3-phosphate transporter), member 3
Mus musculus ENSMUSG00000032122   solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Mus musculus ENSMUSG00000024036   solute carrier family 37 (glycerol-3-phosphate transporter), member 1
Neospora caninum NCLIV_030090   sugar permease, putative
Oryza sativa 4344694   Os08g0156600
Oryza sativa 4340305   Os06g0179900
Oryza sativa 4330176   Os02g0652800
Oryza sativa 4336618   Os04g0555300
Onchocerca volvulus OVOC3987   Sugar phosphate exchanger 3 homolog
Schistosoma japonicum Sjp_0312540   Sugar phosphate exchanger 2, putative
Schistosoma japonicum Sjp_0053160   Sugar phosphate exchanger 2, putative
Schistosoma japonicum Sjp_0215500   Sugar phosphate exchanger 2, putative
Schistosoma mansoni Smp_084600.1   solute carrier family 37 member 2 (glycerol-3-phosphate transporter
Schistosoma mansoni Smp_084600.2   solute carrier family 37 member 2 (glycerol-3-phosphate transporter
Schmidtea mediterranea mk4.017038.00   Putative solute carrier family 37 member 2
Schmidtea mediterranea mk4.011836.00  
Schmidtea mediterranea mk4.001918.06   Sugar phosphate exchanger 3
Schmidtea mediterranea mk4.014719.00  
Schmidtea mediterranea mk4.006636.00   Solute carrier family 37 member 2
Schmidtea mediterranea mk4.017038.01   Putative solute carrier family 37 member 2
Schmidtea mediterranea mk4.027995.00  
Trypanosoma cruzi TcCLB.510661.100   hypothetical protein
Trypanosoma cruzi TcCLB.510741.170   hypothetical protein
Toxoplasma gondii TGME49_229150   transporter, major facilitator family protein
Theileria parva TP01_0403   hypothetical protein

Essentiality

EmuJ_000504900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_229150 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000504900 (Echinococcus multilocularis), sugar phosphate exchanger 3
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