Detailed view for EmuJ_001158900

Basic information

TDR Targets ID: 966032
Echinococcus multilocularis, DNA binding SAP

Source Database / ID:  GeneDB

pI: 4.8199 | Length (AA): 526 | MW (Da): 58417 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08766   DEK C terminal domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
424 480 1q1v (A) 319 375 37.00 0.0023 1 0.744265 -1.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130851)

Species Accession Gene Product
Arabidopsis thaliana AT4G26630   DEK domain-containing chromatin associated protein
Arabidopsis thaliana AT5G63550   DEK domain-containing chromatin associated protein
Arabidopsis thaliana AT5G55660   DEK domain-containing chromatin associated protein
Arabidopsis thaliana AT3G48710   DEK domain-containing chromatin associated protein
Brugia malayi Bm1_14300   DEK protein
Drosophila melanogaster Dmel_CG5935   CG5935 gene product from transcript CG5935-RE
Entamoeba histolytica EHI_065630   hypothetical protein
Entamoeba histolytica EHI_198680   hypothetical protein
Echinococcus multilocularis EmuJ_001158900   DNA binding SAP
Homo sapiens ENSG00000124795   DEK proto-oncogene
Loa Loa (eye worm) LOAG_00224   hypothetical protein
Mus musculus ENSMUSG00000021377   DEK oncogene (DNA binding)
Oryza sativa 4333378   Os03g0596900
Oryza sativa 4327229   Os01g0924900
Onchocerca volvulus OVOC11863   Protein DEK homolog
Schistosoma japonicum Sjp_0008920   Protein DEK, putative
Schistosoma mansoni Smp_059710   hypothetical protein
Schmidtea mediterranea mk4.002171.00   Protein DEK

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001158900 (Echinococcus multilocularis), DNA binding SAP
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