Detailed view for EmuJ_000821100

Basic information

TDR Targets ID: 966045
Echinococcus multilocularis, cyclic nucleotide gated cation channel

Source Database / ID:  GeneDB

pI: 8.4495 | Length (AA): 811 | MW (Da): 91811 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
443 627 3u0z (A) 390 566 31.00 0 1 0.613413 -0.23
443 647 3otf (A) 521 717 28.00 0 1 0.589474 -0.19
492 550 3k1e (A) 55 106 37.00 0.95 0.16 0.13705 1.44
636 715 2xko (A) 130 210 18.00 0.025 0.01 0.348644 -0.94
692 809 5j0l (C) 4 129 17.00 0.75 0.05 0.323499 -0.48
747 807 4c53 (A) 307 368 37.00 0.97 0.13 0.0565158 1.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_139904)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG43395   Cyclic nucleotide-gated ion channel-like
Echinococcus granulosus EgrG_000821100   cyclic nucleotide gated cation channel
Echinococcus multilocularis EmuJ_000821100   cyclic nucleotide gated cation channel
Schistosoma japonicum Sjp_0003830   Cyclic nucleotide-gated channel rod photoreceptor subunit alpha, putative
Schistosoma mansoni Smp_152480   cyclic-nucleotide-gated cation channel
Schmidtea mediterranea mk4.016596.00   Putative cyclic-nucleotide-gated cation channel
Schmidtea mediterranea mk4.013630.00   Cyclic nucleotide-gated ion channel-like

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000821100 (Echinococcus multilocularis), cyclic nucleotide gated cation channel
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