Detailed view for Sjp_0092390

Basic information

TDR Targets ID: 966734
Schistosoma japonicum, Proprotein convertase subtilisin/kexin type 6 precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.4167 | Length (AA): 273 | MW (Da): 30633 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00082   Subtilase family
PF16470   Peptidase S8 pro-domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

Quorum sensing (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
90 265 2id4 (A) 125 297 45.00 0 1 1.23606 -0.65
93 265 5jxg (A) 112 278 56.00 0 1 1.29103 -0.41
135 215 3vhq (A) 109 186 41.00 0.00000017 1 0.850794 -0.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127788)

Species Accession Gene Product
Brugia malayi Bm1_29290   endoprotease bli-4 precursor
Brugia malayi Bm1_55335   celfurPC protein
Candida albicans CaO19.12219   subtilisin-like endoprotease involved in processing C. albicans Sap2
Candida albicans CaO19.4755   subtilisin-like endoprotease involved in processing C. albicans Sap2
Caenorhabditis elegans CELE_F11A6.1   Protein KPC-1, isoform B
Caenorhabditis elegans CELE_K04F10.4   Protein BLI-4, isoform F
Drosophila melanogaster Dmel_CG18734   Furin 2
Drosophila melanogaster Dmel_CG10772   Furin 1
Echinococcus granulosus EgrG_000998900   proprotein convertase subtilisin:kexin type 5
Echinococcus granulosus EgrG_000896900   furin
Echinococcus multilocularis EmuJ_000896900  
Echinococcus multilocularis EmuJ_000998900   proprotein convertase subtilisin:kexin type 5
Giardia lamblia GL50803_22547   High cysteine membrane protein Group 2
Homo sapiens ENSG00000115257   proprotein convertase subtilisin/kexin type 4
Homo sapiens ENSG00000140479   proprotein convertase subtilisin/kexin type 6
Homo sapiens 9159   proprotein convertase subtilisin/kexin type 7
Homo sapiens ENSG00000140564   furin (paired basic amino acid cleaving enzyme)
Loa Loa (eye worm) LOAG_03049   endoprotease bli-4
Loa Loa (eye worm) LOAG_04307   hypothetical protein
Mus musculus ENSMUSG00000020131   proprotein convertase subtilisin/kexin type 4
Mus musculus ENSMUSG00000030513   proprotein convertase subtilisin/kexin type 6
Mus musculus ENSMUSG00000035382   proprotein convertase subtilisin/kexin type 7
Mus musculus ENSMUSG00000030530   furin (paired basic amino acid cleaving enzyme)
Saccharomyces cerevisiae YNL238W   Kex2p
Schistosoma japonicum Sjp_0092390   Proprotein convertase subtilisin/kexin type 6 precursor, putative
Schistosoma japonicum Sjp_0076700   Furin-like protease 1, isoforms 1/1-X/2 precursor, putative
Schistosoma japonicum Sjp_0037780   Endoprotease bli-4 precursor, putative
Schistosoma japonicum Sjp_0134420   hypothetical protein
Schistosoma mansoni Smp_144080   subfamily S8B unassigned peptidase (S08 family)
Schmidtea mediterranea mk4.017780.00  
Schmidtea mediterranea mk4.011318.01  
Schmidtea mediterranea mk4.013463.01  
Schmidtea mediterranea mk4.005150.00   Proprotein convertase subtilisin/kexin type 6
Schmidtea mediterranea mk4.013463.02   Endoprotease bli-4
Schmidtea mediterranea mk4.002533.03   Furin-like protease 2
Trichomonas vaginalis TVAG_184220   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_042330   Clan SB, family S8, subtilisin-like serine peptidase

Essentiality

Sjp_0092390 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K04F10.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_K04F10.4 Caenorhabditis elegans larval arrest wormbase
CELE_K04F10.4 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens proprotein convertase subtilisin/kexin type 4 Compounds References
Homo sapiens furin (paired basic amino acid cleaving enzyme) Compounds References
Homo sapiens proprotein convertase subtilisin/kexin type 7 Compounds References
Rattus norvegicus Proprotein convertase subtilisin/kexin type 6 Compounds References
Homo sapiens proprotein convertase subtilisin/kexin type 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Sjp_0092390 (Schistosoma japonicum), Proprotein convertase subtilisin/kexin type 6 precursor, putative
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