Detailed view for Sjp_0201550

Basic information

TDR Targets ID: 966792
Schistosoma japonicum, expressed protein
Source Database / ID:  Wormbase Parasite  

pI: 10.0807 | Length (AA): 196 | MW (Da): 21558 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03623   Focal adhesion targeting region

Gene Ontology

Mouse over links to read term descriptions.
GO:0005925   focal adhesion  
GO:0004713   protein tyrosine kinase activity  
GO:0007172   signal complex assembly  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130513)

Species Accession Gene Product
Brugia malayi Bm1_48220   Protein kinase domain containing protein
Caenorhabditis elegans CELE_C30F8.4   Protein KIN-32, isoform B
Drosophila melanogaster Dmel_CG10023   Focal adhesion kinase
Echinococcus granulosus EgrG_000060700   protein tyrosine kinase
Echinococcus multilocularis EmuJ_000060700   protein tyrosine kinase
Homo sapiens ENSG00000169398   protein tyrosine kinase 2
Homo sapiens ENSG00000120899   protein tyrosine kinase 2 beta
Loa Loa (eye worm) LOAG_01724   TK/FAK protein kinase
Mus musculus ENSMUSG00000022607   PTK2 protein tyrosine kinase 2
Mus musculus ENSMUSG00000059456   PTK2 protein tyrosine kinase 2 beta
Schistosoma japonicum Sjp_0009120   expressed protein
Schistosoma japonicum Sjp_0201550   expressed protein
Schistosoma japonicum Sjp_0201560   Protein tyrosine kinase 2 beta, putative
Schistosoma mansoni Smp_137610   tyrosine kinase
Schmidtea mediterranea mk4.000021.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein tyrosine kinase 2 beta Compounds References
Mus musculus PTK2 protein tyrosine kinase 2 beta Compounds References
Homo sapiens protein tyrosine kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0201550 (Schistosoma japonicum), expressed protein
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