pI: 9.1484 |
Length (AA): 492 |
MW (Da): 55933 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 384 | 5svk (A) | 7 | 363 | 42.00 | 0 | 1 | 1.12936 | 0.83 |
25 | 366 | 5f1c (B) | 21 | 373 | 44.00 | 0 | 1 | 1.08614 | 0.78 |
117 | 176 | 2rup (A) | 111 | 167 | 32.00 | 0.00000000099 | 0.42 | 0.42 | 0.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_132622)
Species | Accession | Gene Product |
---|---|---|
Echinococcus granulosus | EgrG_000839300 | p2X purinoceptor 4 |
Echinococcus granulosus | EgrG_000815100 | p2X purinoceptor 4 |
Echinococcus granulosus | EgrG_000977600 | p2X purinoceptor 4 |
Echinococcus multilocularis | EmuJ_000977600 | p2X purinoceptor 4 |
Echinococcus multilocularis | EmuJ_000839300 | p2X purinoceptor 4 |
Echinococcus multilocularis | EmuJ_000815100 | p2X purinoceptor 4 |
Homo sapiens | ENSG00000108405 | purinergic receptor P2X, ligand-gated ion channel, 1 |
Homo sapiens | ENSG00000135124 | purinergic receptor P2X, ligand-gated ion channel, 4 |
Mus musculus | ENSMUSG00000020787 | purinergic receptor P2X, ligand-gated ion channel, 1 |
Mus musculus | ENSMUSG00000029470 | purinergic receptor P2X, ligand-gated ion channel 4 |
Schistosoma japonicum | Sjp_0017180 | ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative |
Schistosoma japonicum | Sjp_0017170 | ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative |
Schistosoma mansoni | Smp_176860 | P2X receptor subunit |
Schistosoma mansoni | Smp_099640 | P2X receptor subunit |
Schmidtea mediterranea | mk4.020589.00 | |
Schmidtea mediterranea | mk4.025532.01 | P2X purinoceptor |
Schmidtea mediterranea | mk4.029521.00 | P2X purinoceptor |
Schmidtea mediterranea | mk4.014493.01 | |
Schmidtea mediterranea | mk4.000231.02 | |
Schmidtea mediterranea | mk4.008523.00 | |
Schmidtea mediterranea | mk4.018055.00 | P2X purinoceptor |
Schmidtea mediterranea | mk4.021255.00 | |
Schmidtea mediterranea | mk4.025682.01 | |
Schmidtea mediterranea | mk4.020610.01 | |
Schmidtea mediterranea | mk4.000819.03 | |
Schmidtea mediterranea | mk4.016722.00 | |
Schmidtea mediterranea | mk4.027621.00 | P2X purinoceptor |
Schmidtea mediterranea | mk4.021869.01 | P2X purinoceptor |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 1 | Compounds | References |
Mus musculus | purinergic receptor P2X, ligand-gated ion channel, 1 | Compounds | References |
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 4 | Compounds | References |
Rattus norvegicus | P2X purinoceptor 1 | Compounds | References |
Mus musculus | purinergic receptor P2X, ligand-gated ion channel 4 | Compounds | References |
Rattus norvegicus | P2X purinoceptor 4 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Canis lupus familiaris | P2X7 purinoceptor | 205 aa | 41.0% | 195 aa | Compounds | References |
Rattus norvegicus | P2X2/P2X3 receptor | 397 aa | 38.3% | 399 aa | Compounds | References |
Rattus norvegicus | P2X purinoceptor 3 | 397 aa | 38.3% | 399 aa | Compounds | References |
Rattus norvegicus | P2X purinoceptor 6 | 379 aa | 38.5% | 371 aa | Compounds | References |
Rattus norvegicus | P2X purinoceptor 5 | 455 aa | 43.3% | 372 aa | Compounds | References |