Detailed view for Sjp_0216440

Basic information

TDR Targets ID: 967344
Schistosoma japonicum, ko:K01262 X-Pro aminopeptidase [EC3.4.11.9], putative
Source Database / ID:  Wormbase Parasite  

pI: 7.1689 | Length (AA): 494 | MW (Da): 55647 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00557   Metallopeptidase family M24
PF05195   Aminopeptidase P, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030145   manganese ion binding  
GO:0004177   aminopeptidase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131612)

Species Accession Gene Product
Brugia malayi Bm1_40605   Hyaluronidase family protein
Caenorhabditis elegans CELE_T20B5.3   Protein OGA-1, isoform A
Drosophila melanogaster Dmel_CG5871   O-GlcNAcase
Echinococcus granulosus EgrG_000194500   bifunctional protein NCOAT
Echinococcus multilocularis EmuJ_000194500   bifunctional protein NCOAT
Homo sapiens ENSG00000198408   meningioma expressed antigen 5 (hyaluronidase)
Loa Loa (eye worm) LOAG_08076   hyaluronidase
Loa Loa (eye worm) LOAG_13993   hypothetical protein
Mus musculus ENSMUSG00000025220   meningioma expressed antigen 5 (hyaluronidase)
Schistosoma japonicum Sjp_0131780   Bifunctional protein NCOAT, putative
Schistosoma japonicum Sjp_0076490   ko:K01197 hyaluronoglucosaminidase [EC3.2.1.35], putative
Schistosoma japonicum Sjp_0216440   ko:K01262 X-Pro aminopeptidase [EC3.4.11.9], putative
Schistosoma mansoni Smp_127540   aminopeptidase P homologue (M24 family)
Schistosoma mansoni Smp_000020   Hyaluronidase
Schmidtea mediterranea mk4.012820.00  
Schmidtea mediterranea mk4.019533.00  
Schmidtea mediterranea mk4.018762.00   Bifunctional protein NCOAT
Schmidtea mediterranea mk4.012820.01  
Schmidtea mediterranea mk4.010705.00   Bifunctional protein NCOAT
Schmidtea mediterranea mk4.021900.01  
Schmidtea mediterranea mk4.010705.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Protein O-GlcNAcase Compounds References
Homo sapiens meningioma expressed antigen 5 (hyaluronidase) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus (strain COL) Methionine aminopeptidase 252 aa 23.4% 261 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0216440 (Schistosoma japonicum), ko:K01262 X-Pro aminopeptidase [EC3.4.11.9], putative
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