Detailed view for Sjp_0301330

Basic information

TDR Targets ID: 967383
Schistosoma japonicum, ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.4219 | Length (AA): 537 | MW (Da): 59695 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 10

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133283)

Species Accession Gene Product
Brugia malayi Bm1_31305   vesicular acetylcholine transporter unc-17
Caenorhabditis elegans unc-17   Protein UNC-17, isoform A
Drosophila melanogaster Dmel_CG32848   CG32848 gene product from transcript CG32848-RA
Echinococcus granulosus EgrG_000706700   vesicular acetylcholine transporter
Echinococcus multilocularis EmuJ_000706700   vesicular acetylcholine transporter
Homo sapiens ENSG00000187714   solute carrier family 18 (vesicular acetylcholine transporter), member 3
Loa Loa (eye worm) LOAG_10670   vesicular acetylcholine transporter unc-17
Mus musculus ENSMUSG00000100241   solute carrier family 18 (vesicular monoamine), member 3
Onchocerca volvulus OVOC3879   Vesicular acetylcholine transporter homolog
Schistosoma japonicum Sjp_0301330   ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative
Schistosoma mansoni Smp_046120   vesicular acetylcholine transporter
Schmidtea mediterranea mk4.003582.00  
Schmidtea mediterranea mk4.000911.00  
Schmidtea mediterranea mk4.004733.03  
Schmidtea mediterranea mk4.001642.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Torpedo californica Vesicular acetylcholine transporter Compounds References
Homo sapiens solute carrier family 18 (vesicular acetylcholine transporter), member 3 Compounds References
Rattus norvegicus Vesicular acetylcholine transporter Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Synaptic vesicular amine transporter 517 aa 36.3% 534 aa Compounds References
Rattus norvegicus Synaptic vesicular amine transporter 515 aa 38.8% 472 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0301330 (Schistosoma japonicum), ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative
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