Detailed view for Sjp_0075540

Basic information

TDR Targets ID: 967414
Schistosoma japonicum, ko:K07996 matrix metalloproteinase-16 (membrane-inserted), putative
Source Database / ID:  Wormbase Parasite  

pI: 6.9124 | Length (AA): 331 | MW (Da): 37518 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00045   Hemopexin
PF00413   Matrixin

Gene Ontology

Mouse over links to read term descriptions.
GO:0031012   extracellular matrix  
GO:0008270   zinc ion binding  
GO:0008237   metallopeptidase activity  
GO:0004222   metalloendopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 328 1fbl (A) 171 466 27.00 0 1 1.00624 1.37
4 305 4fvl (A) 178 435 40.00 0 1 1.12345 0.59
4 114 1hy7 (B) 657 754 55.00 0 0.85 0.719664 0.89
133 328 3c7x (A) 317 508 31.00 0 1 0.764239 -0.13
136 275 1hxn (A) 232 360 28.00 0.027 0.91 0.602542 0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129064)

Species Accession Gene Product
Brugia malayi Bm1_41050   Matrixin family protein
Caenorhabditis elegans CELE_H36L18.1   Protein H36L18.1
Drosophila melanogaster Dmel_CG4859   Matrix metalloproteinase 1
Echinococcus granulosus EgrG_000939100   matrix metallopeptidase 7 M10 family
Echinococcus multilocularis EmuJ_000939100   matrix metallopeptidase 7 (M10 family)
Homo sapiens ENSG00000125966   matrix metallopeptidase 24 (membrane-inserted)
Homo sapiens 4325   matrix metallopeptidase 16 (membrane-inserted)
Homo sapiens ENSG00000157227   matrix metallopeptidase 14 (membrane-inserted)
Homo sapiens ENSG00000102996   matrix metallopeptidase 15 (membrane-inserted)
Loa Loa (eye worm) LOAG_02274   matrixin family protein
Loa Loa (eye worm) LOAG_08947   hypothetical protein
Mus musculus ENSMUSG00000028226   matrix metallopeptidase 16
Mus musculus ENSMUSG00000027612   matrix metallopeptidase 24
Mus musculus ENSMUSG00000031790   matrix metallopeptidase 15
Mus musculus ENSMUSG00000000957   matrix metallopeptidase 14 (membrane-inserted)
Onchocerca volvulus OVOC9417   Matrilysin homolog
Schistosoma japonicum Sjp_0121600   IPR002477,Peptidoglycan-binding domain 1;IPR009070,Peptidoglycan binding-like,domain-containing
Schistosoma japonicum Sjp_0075540   ko:K07996 matrix metalloproteinase-16 (membrane-inserted), putative
Schistosoma mansoni Smp_145930   matrix metallopeptidase-7 (M10 family)
Schmidtea mediterranea mk4.003998.02   MMP-like protein
Schmidtea mediterranea mk4.004778.01   Mmp protein
Schmidtea mediterranea mk4.000538.00   MMP-like protein
Schmidtea mediterranea mk4.000538.04   Mmp1 protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens matrix metallopeptidase 15 (membrane-inserted) Compounds References
Homo sapiens matrix metallopeptidase 16 (membrane-inserted) Compounds References
Homo sapiens matrix metallopeptidase 14 (membrane-inserted) Compounds References
Homo sapiens matrix metallopeptidase 24 (membrane-inserted) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Canis familiaris Matrix metalloproteinase-12 38 aa 48.6% 35 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0075540 (Schistosoma japonicum), ko:K07996 matrix metalloproteinase-16 (membrane-inserted), putative
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