Detailed view for Sjp_0210110

Basic information

TDR Targets ID: 967490
Schistosoma japonicum, Folate receptor beta precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.9997 | Length (AA): 266 | MW (Da): 29813 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03024   Folate receptor family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Antifolate resistance (KEGG)
Endocytosis (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133376)

Species Accession Gene Product
Echinococcus granulosus EgrG_000751800   folate receptor beta
Echinococcus multilocularis EmuJ_000751800   folate receptor beta
Homo sapiens ENSG00000110195   folate receptor 1 (adult)
Homo sapiens ENSG00000165457   folate receptor 2 (fetal)
Homo sapiens ENSG00000110203   folate receptor 3 (gamma)
Mus musculus ENSMUSG00000032725   folate receptor 2 (fetal)
Mus musculus ENSMUSG00000001827   folate receptor 1 (adult)
Schistosoma japonicum Sjp_0210110   Folate receptor beta precursor, putative
Schmidtea mediterranea mk4.000126.03  
Schmidtea mediterranea mk4.000126.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens folate receptor 1 (adult) Compounds References
Homo sapiens folate receptor 2 (fetal) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gallus gallus Riboflavin-binding protein 238 aa 27.2% 206 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0210110 (Schistosoma japonicum), Folate receptor beta precursor, putative
Title for this comment
Comment