Detailed view for Sjp_0206310

Basic information

TDR Targets ID: 967861
Schistosoma japonicum, ko:K00623 choline O-acetyltransferase [EC2.3.1.6], putative

Source Database / ID:  Wormbase Parasite  

pI: 6.0628 | Length (AA): 684 | MW (Da): 78590 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00755   Choline/Carnitine o-acyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016746   transferase activity, transferring acyl groups  

Metabolic Pathways

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133080)

Species Accession Gene Product
Brugia malayi Bm1_31300   Choline O-acetyltransferase
Brugia malayi Bm1_31295   Choline O-acetyltransferase
Caenorhabditis elegans cha-1   Protein CHA-1, isoform B
Drosophila melanogaster Dmel_CG12345   Choline acetyltransferase
Echinococcus granulosus EgrG_000706800   choline O acetyltransferase
Echinococcus multilocularis EmuJ_000706800   choline O acetyltransferase
Homo sapiens ENSG00000070748   choline O-acetyltransferase
Loa Loa (eye worm) LOAG_12445   choline O-acetyltransferase
Loa Loa (eye worm) LOAG_12141   hypothetical protein
Mus musculus ENSMUSG00000021919   choline acetyltransferase
Schistosoma japonicum Sjp_0035640   Choline O-acetyltransferase, putative
Schistosoma japonicum Sjp_0206310   ko:K00623 choline O-acetyltransferase [EC2.3.1.6], putative
Schistosoma mansoni Smp_146910   choline o-acyltransferase
Schmidtea mediterranea mk4.003238.01  
Schmidtea mediterranea mk4.026680.00  
Schmidtea mediterranea mk4.009319.00   Choline O-acetyltransferase
Schmidtea mediterranea mk4.002365.07  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens choline O-acetyltransferase Compounds References
Rattus norvegicus Choline acetylase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Carnitine palmitoyltransferase 2 658 aa 26.9% 661 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Sjp_0206310 (Schistosoma japonicum), ko:K00623 choline O-acetyltransferase [EC2.3.1.6], putative
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