Detailed view for Sjp_0069340

Basic information

TDR Targets ID: 967910
Schistosoma japonicum, ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.6941 | Length (AA): 549 | MW (Da): 63016 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00520   Ion transport protein
PF02214   BTB/POZ domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008076   voltage-gated potassium channel complex  
GO:0005515   protein binding  
GO:0005249   voltage-gated potassium channel activity  
GO:0005216   ion channel activity  
GO:0055085   transmembrane transport  
GO:0051260   protein homooligomerization  
GO:0006813   potassium ion transport  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 59 3drx (A) 38 75 29.00 0.001 0.05 0.292017 0.44
26 412 3lnm (D) 31 417 69.00 0 1 1.14252 1.35
27 306 2r9r (B) 32 311 49.00 0.041 1 1.05282 0.19
28 412 3lut (B) 33 421 68.00 0 1 1.32788 1.36
182 214 3bog (C) 3 67 99.99 0 0 1.07771 -0.25
472 548 2mtn (A) 353 427 33.00 0.0086 0.81 0.503855 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127659)

Species Accession Gene Product
Brugia malayi Bm1_24105   Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit
Caenorhabditis elegans CELE_ZK1321.2   Protein SHK-1, isoform G
Drosophila melanogaster Dmel_CG12348   Shaker
Echinococcus granulosus EgrG_001042000   potassium voltage gated channel protein
Echinococcus granulosus EgrG_001018900   potassium voltage gated channel subfamily A
Echinococcus multilocularis EmuJ_001018900   potassium voltage gated channel subfamily A
Echinococcus multilocularis EmuJ_001042000   potassium voltage gated channel protein
Homo sapiens ENSG00000182255   potassium voltage-gated channel, shaker-related subfamily, member 4
Homo sapiens ENSG00000130037   potassium voltage-gated channel, shaker-related subfamily, member 5
Homo sapiens ENSG00000111262   potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Homo sapiens ENSG00000130035   potassium voltage-gated channel, shaker-related subfamily, member 6
Homo sapiens ENSG00000177272   potassium voltage-gated channel, shaker-related subfamily, member 3
Loa Loa (eye worm) LOAG_01893   hypothetical protein
Mus musculus 16490   potassium voltage-gated channel, shaker-related subfamily, member 2
Mus musculus 16493   potassium voltage-gated channel, shaker-related subfamily, member 5
Mus musculus ENSMUSG00000038077   potassium voltage-gated channel, shaker-related, subfamily, member 6
Mus musculus ENSMUSG00000047976   potassium voltage-gated channel, shaker-related subfamily, member 1
Mus musculus ENSMUSG00000042604   potassium voltage-gated channel, shaker-related subfamily, member 4
Mus musculus ENSMUSG00000047959   potassium voltage-gated channel, shaker-related subfamily, member 3
Schistosoma japonicum Sjp_0111850   Potassium voltage-gated channel subfamily A member 5, putative
Schistosoma japonicum Sjp_0069340   ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative
Schistosoma japonicum Sjp_0305890   Potassium voltage-gated channel protein Shaker, putative
Schistosoma mansoni Smp_129380   voltage-gated potassium channel
Schistosoma mansoni Smp_069240   voltage-gated potassium channel
Schmidtea mediterranea mk4.000732.11   Potassium voltage-gated channel protein shk-1
Schmidtea mediterranea mk4.008686.00   Potassium voltage-gated channel protein Shaker
Schmidtea mediterranea mk4.000218.00   Potassium voltage-gated channel protein Shaker
Schmidtea mediterranea mk4.000052.12   Potassium voltage-gated channel protein Shaker
Schmidtea mediterranea mk4.000732.01   Potassium voltage-gated channel protein Shaker
Schmidtea mediterranea mk4.022554.00   Potassium voltage-gated channel protein Shaker
Schmidtea mediterranea mk4.012416.01   Potassium voltage-gated channel protein Shaker
Schmidtea mediterranea mk4.000990.05   Potassium voltage-gated channel protein Shaker

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 4 Compounds References
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) Compounds References
Mus musculus potassium voltage-gated channel, shaker-related subfamily, member 3 Compounds References
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5 Compounds References
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0069340 (Schistosoma japonicum), ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative
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