Detailed view for Sjp_0015720

Basic information

TDR Targets ID: 968582
Schistosoma japonicum, ko:K04422 mitogen-activated protein kinase kinase kinase 13, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.7299 | Length (AA): 710 | MW (Da): 81309 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07714   Protein tyrosine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
233 710 2fo0 (A) 119 529 25.00 0 1 0.57952 1.19
359 727 5cen (A) 118 396 59.00 0 1 0.810023 0.21
621 695 4aoj (A) 707 781 28.00 0 0.78 0.529989 -1.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131367)

Species Accession Gene Product
Brugia malayi Bm1_48405   Protein kinase domain containing protein
Caenorhabditis elegans CELE_F33E2.2a   Protein DLK-1, isoform D
Caenorhabditis elegans CELE_F33E2.2   Protein DLK-1, isoform C
Drosophila melanogaster Dmel_CG8789   wallenda
Echinococcus granulosus EgrG_000341400   mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_000341400   mitogen activated protein kinase kinase kinase
Homo sapiens ENSG00000073803   mitogen-activated protein kinase kinase kinase 13
Homo sapiens ENSG00000139625   mitogen-activated protein kinase kinase kinase 12
Loa Loa (eye worm) LOAG_10583   TKL/MLK/LZK protein kinase
Loa Loa (eye worm) LOAG_10584   hypothetical protein
Loa Loa (eye worm) LOAG_05133   hypothetical protein
Mus musculus ENSMUSG00000033618   mitogen-activated protein kinase kinase kinase 13
Mus musculus ENSMUSG00000023050   mitogen-activated protein kinase kinase kinase 12
Oryza sativa 9270313   Os09g0566500
Schistosoma japonicum Sjp_0015710   Mitogen-activated protein kinase kinase kinase 12, putative
Schistosoma japonicum Sjp_0015720   ko:K04422 mitogen-activated protein kinase kinase kinase 13, putative
Schistosoma mansoni Smp_125370   serine/threonine protein kinase
Schmidtea mediterranea mk4.008454.01  
Schmidtea mediterranea mk4.002532.02   Mitogen-activated protein kinase kinase kinase dlk-1
Schmidtea mediterranea mk4.000171.03   Raf homolog serine/threonine-protein kinase phl

Essentiality

Sjp_0015720 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F33E2.2 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase kinase kinase 12 Compounds References
Homo sapiens mitogen-activated protein kinase kinase kinase 13 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 26.6% 241 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.0% 241 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 34.1% 185 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.1% 234 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 26.7% 180 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0015720 (Schistosoma japonicum), ko:K04422 mitogen-activated protein kinase kinase kinase 13, putative
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