Detailed view for Sjp_0115980

Basic information

TDR Targets ID: 968954
Schistosoma japonicum, ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative
Source Database / ID:  Wormbase Parasite  

pI: 8.1746 | Length (AA): 401 | MW (Da): 45994 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00305   Lipoxygenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016702   oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  
GO:0046872   metal ion binding  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 400 4nre (A) 327 676 27.00 0 1 1.2081 -0.1
1 400 3dy5 (A) 710 1066 25.00 0 1 1.1241 0.34
19 396 3d3l (A) 330 659 31.00 0 1 1.0117 0.4
22 396 3fg1 (A) 730 1062 26.00 0 1 1.1512 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127482)

Species Accession Gene Product
Arabidopsis thaliana AT1G67560   lipoxygenase 6
Arabidopsis thaliana AT3G45140   lipoxygenase 2
Arabidopsis thaliana AT1G55020   lipoxygenase 1
Arabidopsis thaliana AT1G17420   lipoxygenase 3
Arabidopsis thaliana AT1G72520   lipoxygenase 4
Arabidopsis thaliana AT3G22400   lipoxygenase 5
Dictyostelium discoideum DDB_G0279909   hypothetical protein
Echinococcus granulosus EgrG_001097200   arachidonate 5 lipoxygenase
Echinococcus multilocularis EmuJ_001097200   arachidonate 5 lipoxygenase
Homo sapiens ENSG00000012779   arachidonate 5-lipoxygenase
Homo sapiens ENSG00000179148   arachidonate lipoxygenase 3
Homo sapiens ENSG00000179593   arachidonate 15-lipoxygenase, type B
Homo sapiens ENSG00000179477   arachidonate 12-lipoxygenase, 12R type
Mus musculus ENSMUSG00000020891   arachidonate 8-lipoxygenase
Mus musculus ENSMUSG00000020892   arachidonate lipoxygenase 3
Mus musculus ENSMUSG00000032807   arachidonate 12-lipoxygenase, 12R type
Mus musculus ENSMUSG00000025701   arachidonate 5-lipoxygenase
Oryza sativa 4334049   Os03g0738600
Oryza sativa 4333823   Os03g0700700
Oryza sativa 4350766   Os11g0575600
Oryza sativa 4352509   Os12g0560200
Oryza sativa 4328603   Os02g0194700
Oryza sativa 4333821   Os03g0700400
Oryza sativa 4333818   Os03g0699700
Oryza sativa 4352505   Os12g0559200
Oryza sativa 4345994   Os08g0509100
Oryza sativa 4338358   Os05g0304600
Oryza sativa 4345993   Os08g0508800
Oryza sativa 4331824   Os03g0179900
Schistosoma japonicum Sjp_0101650   IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing
Schistosoma japonicum Sjp_0115980   ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative
Schistosoma mansoni Smp_034020   lipoxygenase
Schistosoma mansoni Smp_034010   lipoxygenase
Schmidtea mediterranea mk4.000027.19  
Schmidtea mediterranea mk4.000027.18  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Arachidonate 5-lipoxygenase Compounds References
Glycine max Seed linoleate 9S-lipoxygenase Compounds References
Rattus norvegicus Arachidonate 5-lipoxygenase Compounds References
Glycine max Lipoxygenase Compounds References
Mus musculus arachidonate 5-lipoxygenase Compounds References
Homo sapiens arachidonate 15-lipoxygenase, type B Compounds References
Homo sapiens arachidonate 5-lipoxygenase Compounds References
Glycine max Seed lipoxygenase-1 Compounds References
Rattus norvegicus Arachidonate 15-lipoxygenase, type II Compounds References
Solanum tuberosum 5-lipoxygenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0115980 (Schistosoma japonicum), ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative
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