Detailed view for Sjp_0204220

Basic information

TDR Targets ID: 969032
Schistosoma japonicum, ko:K09637 transmembrane protease, serine 6, putative
Source Database / ID:  Wormbase Parasite  

pI: 4.7907 | Length (AA): 413 | MW (Da): 47536 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00089   Trypsin
PF00431   CUB domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_152949)

Species Accession Gene Product
Homo sapiens ENSG00000005001   protease, serine, 22
Mus musculus ENSMUSG00000045027   protease, serine 22
Schistosoma japonicum Sjp_0204220   ko:K09637 transmembrane protease, serine 6, putative
Schistosoma mansoni Smp_103680   subfamily S1A unassigned peptidase (S01 family)
Schmidtea mediterranea mk4.010080.00   Subfamily S1A unassigned peptidase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Alpha-chymotrypsin 245 aa 30.4% 240 aa Compounds References
Canis lupus familiaris Tryptase 275 aa 30.1% 259 aa Compounds References
Rattus norvegicus Tryptase alpha/beta-1 273 aa 31.1% 251 aa Compounds References
Rattus norvegicus Elastase 2A 271 aa 30.7% 251 aa Compounds References
Sus scrofa Glandular kallikrein 246 aa 29.8% 258 aa Compounds References
Rattus norvegicus Mast cell protease 3 247 aa 20.9% 215 aa Compounds References
Sus scrofa Elastase 1 266 aa 26.5% 257 aa Compounds References
Bos taurus Trypsin I 246 aa 30.6% 242 aa Compounds References
Oryctolagus cuniculus Thrombin 235 aa 31.1% 238 aa Compounds References
Sus scrofa Trypsin 231 aa 28.9% 242 aa Compounds References
Sus scrofa Elastase 2A 269 aa 31.8% 267 aa Compounds References
Canis lupus familiaris Coagulation factor X 159 aa 27.3% 161 aa Compounds References
Sus scrofa Pancreatic elastase 269 aa 31.8% 267 aa Compounds References
Bos taurus Trypsin II 247 aa 29.8% 242 aa Compounds References
Bos taurus Beta-chymotrypsin 245 aa 30.4% 240 aa Compounds References
Rattus norvegicus Trypsin II 246 aa 30.6% 242 aa Compounds References
Rattus norvegicus Anionic trypsin-1 246 aa 31.0% 242 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Sjp_0204220 (Schistosoma japonicum), ko:K09637 transmembrane protease, serine 6, putative
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