Detailed view for Sjp_0202280

Basic information

TDR Targets ID: 969249
Schistosoma japonicum, ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.7217 | Length (AA): 437 | MW (Da): 49410 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00864   ATP P2X receptor

Gene Ontology

Mouse over links to read term descriptions.
GO:0004931   ATP-gated cation channel activity  
GO:0001614   purinergic nucleotide receptor activity  
GO:0098655   GO:cation transmembrane transport  

GO:0033198   response to ATP  
GO:0005887   integral to plasma membrane  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_246672)

Species Accession Gene Product
Schistosoma japonicum Sjp_0202280   ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative
Schmidtea mediterranea mk4.003738.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus P2X purinoceptor 1 399 aa 41.0% 371 aa Compounds References
Rattus norvegicus P2X purinoceptor 6 379 aa 36.0% 381 aa Compounds References
Rattus norvegicus P2X purinoceptor 4 388 aa 46.0% 359 aa Compounds References
Canis lupus familiaris P2X7 purinoceptor 205 aa 32.3% 195 aa Compounds References
Rattus norvegicus P2X2/P2X3 receptor 397 aa 37.0% 403 aa Compounds References
Rattus norvegicus P2X purinoceptor 3 397 aa 37.0% 403 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0202280 (Schistosoma japonicum), ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative
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