Detailed view for Sjp_0046440

Basic information

TDR Targets ID: 969481
Schistosoma japonicum, Non-lysosomal glucosylceramidase, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.4782 | Length (AA): 566 | MW (Da): 64774 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04685   Glycosyl-hydrolase family 116, catalytic region

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 504 5fjs (A) 371 799 36.00 0 1 1.10534 0.26
109 505 5o0s (A) 421 800 34.00 0 1 1.09275 -0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130651)

Species Accession Gene Product
Arabidopsis thaliana AT1G33700   Beta-glucosidase, GBA2 type protein
Arabidopsis thaliana AT4G10060   beta-glucosidase, GBA2 type family protein
Arabidopsis thaliana AT5G49900   Beta-glucosidase, GBA2 type family protein
Arabidopsis thaliana AT3G24180   Beta-glucosidase, GBA2 type family protein
Caenorhabditis elegans CELE_R08F11.1   Protein R08F11.1
Caenorhabditis elegans CELE_Y105E8A.10   Protein HPO-13, isoform C
Dictyostelium discoideum DDB_G0292446   hypothetical protein
Drosophila melanogaster Dmel_CG33090   CG33090 gene product from transcript CG33090-RE
Echinococcus granulosus EgrG_000876700   non lysosomal glucosylceramidase
Echinococcus granulosus EgrG_000822700   bile acid beta glucosidase
Echinococcus multilocularis EmuJ_000822700   bile acid beta glucosidase
Echinococcus multilocularis EmuJ_000876700   non lysosomal glucosylceramidase
Homo sapiens ENSG00000070610   glucosidase, beta (bile acid) 2
Loa Loa (eye worm) LOAG_09338   hypothetical protein
Mus musculus ENSMUSG00000028467   glucosidase beta 2
Oryza sativa 4348876   Os10g0473400
Oryza sativa 4350171   Os11g0242100
Oryza sativa 9268048   Os07g0444000
Oryza sativa 4344485   Os08g0111200
Schistosoma japonicum Sjp_0046440   Non-lysosomal glucosylceramidase, putative
Schistosoma japonicum Sjp_0312230   Non-lysosomal glucosylceramidase, putative
Schistosoma japonicum Sjp_0046460   Non-lysosomal glucosylceramidase, putative
Schistosoma mansoni Smp_155750.1   bile acid beta-glucosidase-related
Schistosoma mansoni Smp_155750.2   bile acid beta-glucosidase-related

Essentiality

Sjp_0046440 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R08F11.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens glucosidase, beta (bile acid) 2 Compounds References
Mus musculus glucosidase beta 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0046440 (Schistosoma japonicum), Non-lysosomal glucosylceramidase, putative
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