Detailed view for Sjp_0037920

Basic information

TDR Targets ID: 969752
Schistosoma japonicum, ko:K06070 protein kinase D, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.6139 | Length (AA): 361 | MW (Da): 41685 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004697   protein kinase C activity  
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 360 2xrw (A) 18 363 25.00 0 1 0.841544 0.1
4 309 3c0g (B) 5 298 32.00 0 1 1.1751 -0.68
8 288 2y7j (A) 18 292 32.00 0 1 1.06466 -0.77
11 350 4ysj (A) 28 351 32.00 0 1 1.28474 -0.65
108 252 3vut (A) 200 325 41.00 0.016 0.7 0.204078 1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130080)

Species Accession Gene Product
Brugia malayi Bm1_50250   Phorbol esters/diacylglycerol binding domain
Brugia malayi Bm1_26110   C1-like domain containing protein
Caenorhabditis elegans CELE_W09C5.5   Protein DKF-1
Caenorhabditis elegans CELE_T25E12.4   Protein DKF-2, isoform F
Caenorhabditis elegans CELE_T25E12.4a   Protein DKF-2, isoform D
Drosophila melanogaster Dmel_CG7125   Protein Kinase D
Homo sapiens ENSG00000184304   protein kinase D1
Homo sapiens ENSG00000105287   protein kinase D2
Homo sapiens ENSG00000115825   protein kinase D3
Loa Loa (eye worm) LOAG_12666   hypothetical protein
Loa Loa (eye worm) LOAG_02477   hypothetical protein
Loa Loa (eye worm) LOAG_02476   hypothetical protein
Loa Loa (eye worm) LOAG_02478   hypothetical protein
Loa Loa (eye worm) LOAG_11310   CAMK/PKD protein kinase
Loa Loa (eye worm) LOAG_05407   CAMK/PKD protein kinase
Mus musculus ENSMUSG00000024070   protein kinase D3
Mus musculus ENSMUSG00000041187   protein kinase D2
Mus musculus ENSMUSG00000002688   protein kinase D1
Onchocerca volvulus OVOC7047  
Onchocerca volvulus OVOC7045  
Onchocerca volvulus OVOC7046  
Schistosoma japonicum Sjp_0037940   hypothetical protein
Schistosoma japonicum Sjp_0037920   ko:K06070 protein kinase D, putative
Schistosoma japonicum Sjp_0121920   ko:K06070 protein kinase D, putative
Schistosoma japonicum Sjp_0037910   expressed protein
Schistosoma japonicum Sjp_0037900   hypothetical protein
Schistosoma mansoni Smp_155950   protein kinase C mu

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein kinase D3 Compounds References
Homo sapiens protein kinase D2 Compounds References
Homo sapiens protein kinase D1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus MAP kinase p38 alpha 360 aa 26.5% 362 aa Compounds References
Patiria pectinifera Cdc2 300 aa 26.6% 308 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 27.3% 311 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.0% 311 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 26.3% 308 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 29.2% 319 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 21.7% 313 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 35.3% 170 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 26.6% 109 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 28.8% 319 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 28.2% 319 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.1% 306 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 29.6% 280 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0037920 (Schistosoma japonicum), ko:K06070 protein kinase D, putative
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