Detailed view for Sjp_0066930

Basic information

TDR Targets ID: 969771
Schistosoma japonicum, ko:K08873 PI-3-kinase-related kinase SMG-1, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.855 | Length (AA): 3923 | MW (Da): 440361 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00454   Phosphatidylinositol 3- and 4-kinase
PF02260   FATC domain
PF12796   Ankyrin repeats (3 copies)
PF15785   Serine/threonine-protein kinase smg-1

Gene Ontology

Mouse over links to read term descriptions.
GO:0000184   nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
GO:0016301   kinase activity  
GO:0005515   protein binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0016310   phosphorylation  

Metabolic Pathways

mRNA surveillance pathway (KEGG)

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 201 3b7b (A) 748 917 27.00 0.052 1 0.36311 -0.29
56 142 4hrm (B) 33 126 43.00 0.0000062 1 0.440183 0.22
57 150 2he0 (A) 117 210 28.00 0.56 1 0.503967 -1.1
66 162 1n0r (A) 4 100 33.00 0.0000051 1 0.583732 -1.39
171 259 2zgd (A) 25 110 12.00 0.000001 0.07 0.202393 -1.06
172 253 1ycs (B) 362 439 9.00 0.0089 0.02 0.0946077 -0.45
268 1048 2x1g (F) 76 910 9.00 0 0.7 0.233233 0.35
1285 2218 2x19 (B) 20 943 11.00 0 1 0.315244 0.2
1641 2407 1qgr (A) 22 805 11.00 0 0.67 0.193663 0.41
2176 2857 5wby (B) 1807 2545 22.00 0 1 0.200591 0.5
2632 2735 5dxu (A) 839 942 39.00 0.048 0.39 0.0845171 1.01
3439 3916 4gmo (A) 68 623 11.00 0 0.38 0.146977 0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131142)

Species Accession Gene Product
Brugia malayi Bm1_48115   Phosphatidylinositol 3- and 4-kinase family protein
Brugia malayi Bm1_48110   hypothetical protein
Caenorhabditis elegans CELE_C48B6.6   Protein SMG-1, isoform B
Dictyostelium discoideum DDB_G0275845   PIKK family protein kinase
Drosophila melanogaster Dmel_CG32743   no-on-and-no-off transient C
Echinococcus granulosus EgrG_000444400   serine:threonine protein kinase SMG1
Echinococcus multilocularis EmuJ_000444400   serine:threonine protein kinase SMG1
Homo sapiens 101060386   serine/threonine-protein kinase SMG1-like
Homo sapiens ENSG00000157106   SMG1 phosphatidylinositol 3-kinase-related kinase
Homo sapiens 101060596   serine/threonine-protein kinase SMG1-like
Loa Loa (eye worm) LOAG_15020   hypothetical protein
Loa Loa (eye worm) LOAG_08420   hypothetical protein
Loa Loa (eye worm) LOAG_07367   hypothetical protein
Loa Loa (eye worm) LOAG_10772   hypothetical protein
Mus musculus ENSMUSG00000030655   SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Oryza sativa 4334045   Os03g0738100
Schistosoma japonicum Sjp_0066930   ko:K08873 PI-3-kinase-related kinase SMG-1, putative
Schistosoma mansoni Smp_118260   hypothetical protein
Schistosoma mansoni Smp_142710   fkbp-rapamycin associated protein
Schmidtea mediterranea mk4.008791.03   Serine/threonine-protein kinase smg-1
Schmidtea mediterranea mk4.008142.00   SMG-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SMG1 phosphatidylinositol 3-kinase-related kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0066930 (Schistosoma japonicum), ko:K08873 PI-3-kinase-related kinase SMG-1, putative
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