Detailed view for Sjp_0305000

Basic information

TDR Targets ID: 970261
Schistosoma japonicum, ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative
Source Database / ID:  Wormbase Parasite  

pI: 7.9982 | Length (AA): 235 | MW (Da): 26446 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131459)

Species Accession Gene Product
Brugia malayi Bm1_33990   Protein kinase domain containing protein
Caenorhabditis elegans CELE_F46G11.3   Protein TAG-257
Drosophila melanogaster Dmel_CG1107   auxillin
Echinococcus granulosus EgrG_000077000   cyclin g associated kinase
Echinococcus multilocularis EmuJ_000077000   cyclin g associated kinase
Homo sapiens ENSG00000116675   DnaJ (Hsp40) homolog, subfamily C, member 6
Homo sapiens ENSG00000178950   cyclin G associated kinase
Loa Loa (eye worm) LOAG_08843   NAK/GAK protein kinase
Loa Loa (eye worm) LOAG_06465   hypothetical protein
Mus musculus ENSMUSG00000028528   DnaJ (Hsp40) homolog, subfamily C, member 6
Mus musculus ENSMUSG00000062234   cyclin G associated kinase
Schistosoma japonicum Sjp_0305000   ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative
Schistosoma japonicum Sjp_0101720   Cyclin G-associated kinase, putative
Schistosoma japonicum Sjp_0133000   ko:K09526 DnaJ homolog, subfamily C, member 6, putative
Schistosoma japonicum Sjp_0067780   ko:K08855 cyclin G-associated kinase, putative
Schistosoma mansoni Smp_047190   serine/threonine protein kinase
Schmidtea mediterranea mk4.000774.10  

Essentiality

Sjp_0305000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F46G11.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cyclin G associated kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Casein kinase I isoform alpha 125 aa 25.4% 114 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0305000 (Schistosoma japonicum), ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative
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