Detailed view for Sjp_0037230
Basic information
TDR Targets ID: 970723
Schistosoma japonicum, ko:K04534 guanine nucleotide binding protein (G protein), alpha o polypeptide, putative
Source Database / ID: Wormbase Parasite
Schistosoma japonicum, ko:K04534 guanine nucleotide binding protein (G protein), alpha o polypeptide, putative
Source Database / ID: Wormbase Parasite
pI: 4.861 |
Length (AA): 337 |
MW (Da): 38568 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00503
G-protein alpha subunit
Gene Ontology
Mouse over links to read term descriptions.
GO:0031683
G-protein beta/gamma-subunit binding GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0019001 guanyl nucleotide binding
GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0007165 signal transduction
Metabolic Pathways
Rap1 signaling pathway (KEGG)
Circadian entrainment (KEGG)
Retrograde endocannabinoid signaling (KEGG)
Glutamatergic synapse (KEGG)
Cholinergic synapse (KEGG)
Serotonergic synapse (KEGG)
GABAergic synapse (KEGG)
Dopaminergic synapse (KEGG)
Long-term depression (KEGG)
Estrogen signaling pathway (KEGG)
Melanogenesis (KEGG)
Oxytocin signaling pathway (KEGG)
Morphine addiction (KEGG)
Alcoholism (KEGG)
Chagas disease (KEGG)
Toxoplasmosis (KEGG)
Circadian entrainment (KEGG)
Retrograde endocannabinoid signaling (KEGG)
Glutamatergic synapse (KEGG)
Cholinergic synapse (KEGG)
Serotonergic synapse (KEGG)
GABAergic synapse (KEGG)
Dopaminergic synapse (KEGG)
Long-term depression (KEGG)
Estrogen signaling pathway (KEGG)
Melanogenesis (KEGG)
Oxytocin signaling pathway (KEGG)
Morphine addiction (KEGG)
Alcoholism (KEGG)
Chagas disease (KEGG)
Toxoplasmosis (KEGG)
Structural information
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 4 | 336 | 1bof (A) | 23 | 354 | 65.00 | 0 | 1 | 1.72127 | -0.78 |
| 13 | 330 | 1fqj (A) | 28 | 344 | 63.00 | 0 | 1 | 1.79063 | -1.42 |
| 16 | 328 | 3c7k (A) | 35 | 346 | 80.00 | 0 | 1 | 1.90875 | -1.25 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126802)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT2G26300 | guanine nucleotide-binding protein alpha-1 subunit |
| Brugia malayi | Bm1_40550 | guanine nucleotide-binding protein alpha-7 subunit, putative |
| Brugia malayi | Bm1_35125 | GTP-binding regulatory protein alpha chain - starfish, putative |
| Brugia malayi | Bm1_51340 | Guanine nucleotide-binding protein alpha-3 subunit, putative |
| Candida albicans | CaO19.4015 | likely G-protein alpha subunit capable of functional substitution for S. cerevisiae GPA1 (YHR005C) component of pheromone respon |
| Candida albicans | CaO19.9189 | similar to G-alpha protein, glucose-induced activation of plasma membrane ATPase |
| Candida albicans | CaO19.11498 | G-protein alpha subunit capable of functional substitution for S. cerevisiae GPA1 (YHR005C) component of pheromone response path |
| Candida albicans | CaO19.1621 | similar to G-alpha protein, glucose-induced activation of plasma membrane ATPase |
| Caenorhabditis elegans | CELE_R10H10.5 | Protein GPA-7 |
| Caenorhabditis elegans | CELE_C34D1.3 | Protein ODR-3 |
| Caenorhabditis elegans | CELE_C26C6.2 | Protein GOA-1 |
| Caenorhabditis elegans | CELE_T07A9.7 | Protein GPA-4 |
| Caenorhabditis elegans | CELE_Y95B8A.5 | Protein GPA-16 |
| Dictyostelium discoideum | DDB_G0286185 | G-protein subunit alpha 5 |
| Dictyostelium discoideum | DDB_G0285425 | G-protein subunit alpha 4 |
| Dictyostelium discoideum | DDB_G0283151 | G-protein subunit alpha 6 |
| Dictyostelium discoideum | DDB_G0276267 | G-protein subunit alpha 2 |
| Dictyostelium discoideum | DDB_G0283349 | G-protein subunit alpha 1 |
| Drosophila melanogaster | Dmel_CG2204 | G protein alpha o subunit |
| Drosophila melanogaster | Dmel_CG10060 | G protein alpha i subunit |
| Echinococcus granulosus | EgrG_000150800 | gtp binding protein I alpha 1subunit |
| Echinococcus granulosus | EgrG_001157600 | guanine nucleotide binding protein G protein |
| Echinococcus granulosus | EgrG_001157400 | guanine nucleotide binding protein G protein |
| Entamoeba histolytica | EHI_140350 | G protein alpha subunit, putative |
| Echinococcus multilocularis | EmuJ_001157400 | guanine nucleotide binding protein (G protein) |
| Echinococcus multilocularis | EmuJ_000150800 | gtp binding protein (I) alpha 1subunit |
| Echinococcus multilocularis | EmuJ_001157600 | guanine nucleotide binding protein (G protein) |
| Homo sapiens | ENSG00000134183 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 |
| Homo sapiens | 2773 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
| Homo sapiens | ENSG00000127955 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
| Homo sapiens | ENSG00000087258 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O |
| Homo sapiens | ENSG00000114353 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
| Homo sapiens | ENSG00000214415 | guanine nucleotide binding protein, alpha transducing 3 |
| Loa Loa (eye worm) | LOAG_05154 | GTP-binding regulatory protein alpha chain |
| Loa Loa (eye worm) | LOAG_15095 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_12372 | heterotrimeric G protein alpha subunit |
| Loa Loa (eye worm) | LOAG_04754 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_13532 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_15202 | hypothetical protein |
| Mus musculus | ENSMUSG00000031748 | guanine nucleotide binding protein, alpha O |
| Mus musculus | ENSMUSG00000057614 | guanine nucleotide binding protein (G protein), alpha inhibiting 1 |
| Mus musculus | ENSMUSG00000000001 | guanine nucleotide binding protein (G protein), alpha inhibiting 3 |
| Mus musculus | ENSMUSG00000028777 | guanine nucleotide binding protein, alpha transducing 3 |
| Mus musculus | ENSMUSG00000009108 | guanine nucleotide binding protein, alpha transducing 2 |
| Mus musculus | ENSMUSG00000032562 | guanine nucleotide binding protein (G protein), alpha inhibiting 2 |
| Oryza sativa | 9272594 | Os05g0341300 |
| Oryza sativa | 4338448 | Os05g0333200 |
| Saccharomyces cerevisiae | YER020W | guanine nucleotide-binding protein subunit alpha |
| Saccharomyces cerevisiae | YHR005C | guanine nucleotide-binding protein subunit alpha |
| Schistosoma japonicum | Sjp_0019060 | Guanine nucleotide-binding protein G(i) subunit alpha, putative |
| Schistosoma japonicum | Sjp_0095470 | Guanine nucleotide-binding protein G(i) subunit alpha, putative |
| Schistosoma japonicum | Sjp_0213070 | Guanine nucleotide-binding protein G(i) subunit alpha-1, putative |
| Schistosoma japonicum | Sjp_0083810 | Guanine nucleotide-binding protein G(i) subunit alpha, putative |
| Schistosoma japonicum | Sjp_0122040 | Guanine nucleotide-binding protein G(i) subunit alpha, putative |
| Schistosoma japonicum | Sjp_0037230 | ko:K04534 guanine nucleotide binding protein (G protein), alpha o polypeptide, putative |
| Schistosoma mansoni | Smp_016250.1 | GTP-binding protein (I) alpha-2 subunit gnai2 |
| Schistosoma mansoni | Smp_016250.2 | GTP-binding protein (I) alpha-2 subunit gnai2 |
| Schistosoma mansoni | Smp_016630.1 | trimeric G-protein alpha o subunit |
| Schistosoma mansoni | Smp_020080.1 | GTP-binding protein (I) alpha-1subunit gnai1 |
| Schistosoma mansoni | Smp_020080.2 | GTP-binding protein (I) alpha-1subunit gnai1 |
| Schmidtea mediterranea | mk4.003615.00 | |
| Schmidtea mediterranea | mk4.006953.01 | |
| Schmidtea mediterranea | mk4.016832.00 | |
| Schmidtea mediterranea | mk4.000771.04 | Guanine nucleotide-binding protein alpha-6 subunit |
| Schmidtea mediterranea | mk4.001031.01 | G protein alpha subunit |
| Schmidtea mediterranea | mk4.003887.00 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.005884.02 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.021023.00 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.019448.00 | |
| Schmidtea mediterranea | mk4.011166.02 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.006693.03 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.003497.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.018021.00 | |
| Schmidtea mediterranea | mk4.024017.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.002436.06 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.001937.01 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.010700.00 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.000897.11 | |
| Schmidtea mediterranea | mk4.000560.06 | |
| Schmidtea mediterranea | mk4.009212.00 | |
| Schmidtea mediterranea | mk4.000714.01 | |
| Schmidtea mediterranea | mk4.006273.00 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.023438.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.011317.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000051.08 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.055596.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.003888.03 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.005746.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.028183.00 | |
| Schmidtea mediterranea | mk4.027187.00 | |
| Schmidtea mediterranea | mk4.005711.01 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000662.03 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.028708.00 | Guanine nucleotide-binding protein alpha-16 subunit |
| Schmidtea mediterranea | mk4.000333.14 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.012788.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000081.08 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.013406.02 | |
| Schmidtea mediterranea | mk4.007734.02 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000909.03 | |
| Schmidtea mediterranea | mk4.013497.03 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.002824.04 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.004230.01 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000227.11 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.005704.03 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000153.24 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.006081.01 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.019114.00 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.033715.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.006197.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.005729.01 | Guanine nucleotide-binding protein alpha-16 subunit |
| Schmidtea mediterranea | mk4.000945.00 | |
| Schmidtea mediterranea | mk4.006902.00 | |
| Schmidtea mediterranea | mk4.000771.06 | |
| Schmidtea mediterranea | mk4.002579.08 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.000084.22 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.003185.00 | |
| Schmidtea mediterranea | mk4.013844.00 | Guanine nucleotide-binding protein alpha-16 subunit |
| Schmidtea mediterranea | mk4.005729.00 | |
| Schmidtea mediterranea | mk4.008543.00 | |
| Schmidtea mediterranea | mk4.001070.01 | |
| Schmidtea mediterranea | mk4.000891.10 | |
| Schmidtea mediterranea | mk4.023505.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.005775.04 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.008305.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.017355.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.009732.02 | |
| Schmidtea mediterranea | mk4.002844.03 | |
| Schmidtea mediterranea | mk4.003960.01 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.012375.01 | |
| Schmidtea mediterranea | mk4.000051.09 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.006445.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.047130.00 | Guanine nucleotide-binding protein alpha-16 subunit |
| Schmidtea mediterranea | mk4.005979.02 | |
| Schmidtea mediterranea | mk4.025460.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000153.20 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.000016.04 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.001836.00 | |
| Schmidtea mediterranea | mk4.023096.02 | |
| Schmidtea mediterranea | mk4.003234.04 | |
| Schmidtea mediterranea | mk4.026945.02 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.021322.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000208.05 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.001220.03 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.005708.03 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.007547.00 | |
| Schmidtea mediterranea | mk4.001122.00 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.004663.01 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.021135.00 | Putative gtp-binding protein |
| Schmidtea mediterranea | mk4.003329.05 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.000704.05 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000026.24 | Putative trimeric G-protein alpha o subunit |
| Schmidtea mediterranea | mk4.000020.05 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.001155.06 | |
| Schmidtea mediterranea | mk4.020928.00 | Guanine nucleotide-binding protein G(o) subunit alpha |
| Schmidtea mediterranea | mk4.000159.13 | |
| Trichomonas vaginalis | TVAG_374970 | GTP-binding protein (z) alpha subunit, gnaz, putative |
| Trichomonas vaginalis | TVAG_490430 | G protein (olf) alpha subunit, gnal, putative |
| Trichomonas vaginalis | TVAG_274750 | GTP-binding protein alpha subunit, gna, putative |
| Trichomonas vaginalis | TVAG_452120 | GTP-binding protein alpha subunit, gna, putative |
Essentiality
Sjp_0037230 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| CELE_C26C6.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C26C6.2 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_Y95B8A.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_Y95B8A.5 | Caenorhabditis elegans | sterile | wormbase |
| YHR005C | Saccharomyces cerevisiae | inviable | yeastgenome |
-
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | Compounds | References |
| Homo sapiens | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | Compounds | References |
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
No user comments are available for this gene.
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