Detailed view for Sjp_0032970

Basic information

TDR Targets ID: 971105
Schistosoma japonicum, hypothetical protein
Source Database / ID:  Wormbase Parasite  

pI: 5.7901 | Length (AA): 84 | MW (Da): 9684 | Paralog Number: 9

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 79 3gfb (A) 262 345 31.00 0.63 0.2 0.897259 2.37
42 82 2r9r (B) 259 299 15.00 0.25 0.05 0.669776 -0.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128920)

Species Accession Gene Product
Arabidopsis thaliana AT3G02850   potassium channel SKOR
Arabidopsis thaliana AT5G37500   potassium channel GORK
Drosophila melanogaster Dmel_CG8585   I[[h]] channel
Echinococcus granulosus EgrG_001054100   hyperpolarization activated cyclic
Echinococcus granulosus EgrG_001053800   hyperpolarization activated cyclic
Echinococcus granulosus EgrG_000169800   potassium:sodium hyperpolarization activated
Echinococcus multilocularis EmuJ_001054100   hyperpolarization activated cyclic
Echinococcus multilocularis EmuJ_001053800   hyperpolarization activated cyclic
Echinococcus multilocularis EmuJ_000169800   potassium:sodium hyperpolarization activated
Homo sapiens ENSG00000138622   hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Homo sapiens 348980   hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Homo sapiens ENSG00000099822   hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Homo sapiens ENSG00000143630   hyperpolarization activated cyclic nucleotide-gated potassium channel 3
Mus musculus ENSMUSG00000020331   hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Mus musculus ENSMUSG00000028051   hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Mus musculus 15165   hyperpolarization-activated, cyclic nucleotide-gated K+ 1
Mus musculus ENSMUSG00000032338   hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Schistosoma japonicum Sjp_0086710   Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, putative
Schistosoma japonicum Sjp_0043050   Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, putative
Schistosoma japonicum Sjp_0032950   Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, putative
Schistosoma japonicum Sjp_0032970   hypothetical protein
Schistosoma japonicum Sjp_0043070   Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative
Schistosoma japonicum Sjp_0068230   ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative
Schistosoma japonicum Sjp_0043080   Conserved hypothetical protein
Schistosoma japonicum Sjp_0068240   Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, putative
Schistosoma japonicum Sjp_0032960   Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, putative
Schistosoma japonicum Sjp_0032980   IPR013621,Ion transport N-terminal,domain-containing
Schistosoma mansoni Smp_174860   hyperpolarization activated cyclic nucleotide-gated potassium channel
Schistosoma mansoni Smp_168880   hyperpolarization activated cyclic nucleotide-gated potassium channel
Schistosoma mansoni Smp_153100   hyperpolarization activated cyclic nucleotide-gated potassium channel
Schmidtea mediterranea mk4.002334.02  
Schmidtea mediterranea mk4.021033.02   Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative
Schmidtea mediterranea mk4.020548.00   I+AFsAWw-h+AF0AXQ- channel
Schmidtea mediterranea mk4.020548.01   Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative
Schmidtea mediterranea mk4.000906.05   Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
Schmidtea mediterranea mk4.006769.01   I+AFsAWw-h+AF0AXQ- channel
Schmidtea mediterranea mk4.024152.01   Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative
Schmidtea mediterranea mk4.004890.00   I+AFsAWw-h+AF0AXQ- channel
Schmidtea mediterranea mk4.001755.01   Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative
Schmidtea mediterranea mk4.001755.00   I+AFsAWw-h+AF0AXQ- channel
Schmidtea mediterranea mk4.000906.06  
Schmidtea mediterranea mk4.018412.00   Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative
Schmidtea mediterranea mk4.014789.00  
Schmidtea mediterranea mk4.022649.03  
Schmidtea mediterranea mk4.006769.00   I+AFsAWw-h+AF0AXQ- channel
Schmidtea mediterranea mk4.018865.00  
Schmidtea mediterranea mk4.002334.01   I+AFsAWw-h+AF0AXQ- channel
Trichomonas vaginalis TVAG_147120   voltage and ligand gated potassium channel, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus hyperpolarization-activated, cyclic nucleotide-gated K+ 1 Compounds References
Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 Compounds References
Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 3 Compounds References
Mus musculus hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Compounds References
Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 1 Compounds References
Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0032970 (Schistosoma japonicum), hypothetical protein
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