Detailed view for Sjp_0030520

Basic information

TDR Targets ID: 971185
Schistosoma japonicum, ko:K08291 G protein-coupled receptor kinase [EC2.7.11.16], putative
Source Database / ID:  Wormbase Parasite  

pI: 8.1282 | Length (AA): 611 | MW (Da): 70202 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00615   Regulator of G protein signaling domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004703   G-protein coupled receptor kinase activity  
GO:0004672   protein kinase activity  
GO:0007165   signal transduction  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 548 3nyn (A) 2 538 51.00 0 1 1.43982 -0.26
15 547 4tnd (A) 15 537 51.00 0 1 1.47727 -0.7
25 535 4yhj (B) 25 526 52.00 0 1 1.4342 -0.53
33 607 3v5w (A) 33 614 29.00 0 1 1.16482 0.38
63 183 1agr (E) 61 174 16.00 0 0.9 0.443561 -1.42
71 188 1zv4 (X) 90 201 18.00 0 0.99 0.452643 -1.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130334)

Species Accession Gene Product
Brugia malayi Bm1_31020   Probable G protein-coupled receptor kinase F19C6.1, putative
Brugia malayi Bm1_31030   Probable G protein-coupled receptor kinase F19C6.1, putative
Caenorhabditis elegans CELE_F19C6.1   Protein GRK-1
Drosophila melanogaster Dmel_CG17998   G protein-coupled receptor kinase 2
Echinococcus granulosus EgrG_000973800   [G-protein-coupledreceptor] kinase
Echinococcus multilocularis EmuJ_000973800   G protein coupled receptor kinase 6
Homo sapiens ENSG00000198055   G protein-coupled receptor kinase 6
Homo sapiens ENSG00000198873   G protein-coupled receptor kinase 5
Homo sapiens ENSG00000125388   G protein-coupled receptor kinase 4
Loa Loa (eye worm) LOAG_16097   G protein-coupled receptor kinase 1
Loa Loa (eye worm) LOAG_13169   AGC/GRK/GRK protein kinase
Loa Loa (eye worm) LOAG_09581   AGC/GRK/GRK protein kinase
Mus musculus ENSMUSG00000052783   G protein-coupled receptor kinase 4
Mus musculus ENSMUSG00000003228   G protein-coupled receptor kinase 5
Mus musculus ENSMUSG00000074886   G protein-coupled receptor kinase 6
Schistosoma japonicum Sjp_0079240   G protein-coupled receptor kinase 1, putative
Schistosoma japonicum Sjp_0030520   ko:K08291 G protein-coupled receptor kinase [EC2.7.11.16], putative
Schistosoma mansoni Smp_123640   serine/threonine protein kinase
Schmidtea mediterranea mk4.018292.00   G protein-coupled receptor kinase 1
Schmidtea mediterranea mk4.005219.02  
Schmidtea mediterranea mk4.005219.00  
Schmidtea mediterranea mk4.005219.01  
Schmidtea mediterranea mk4.027629.01   G protein-coupled receptor kinase 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens G protein-coupled receptor kinase 5 Compounds References
Homo sapiens G protein-coupled receptor kinase 6 Compounds References
Homo sapiens G protein-coupled receptor kinase 4 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 32.9% 301 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 33.6% 301 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 32.8% 287 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0030520 (Schistosoma japonicum), ko:K08291 G protein-coupled receptor kinase [EC2.7.11.16], putative
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