Detailed view for Sjp_0017180

Basic information

TDR Targets ID: 971476
Schistosoma japonicum, ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative
Source Database / ID:  Wormbase Parasite  

pI: 9.5125 | Length (AA): 613 | MW (Da): 70124 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00864   ATP P2X receptor

Gene Ontology

Mouse over links to read term descriptions.
GO:0001614   purinergic nucleotide receptor activity  
GO:0098655   GO:cation transmembrane transport  

GO:0033198   response to ATP  
GO:0004931   ATP-gated cation channel activity  
GO:0005887   integral to plasma membrane  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 378 5svk (A) 8 361 42.00 0 1 0.945573 0.85
21 362 5f1c (B) 21 373 43.00 0 1 0.931724 0.66
113 172 2rup (A) 111 167 32.00 0.0000000021 0.42 0.383139 0.03
384 588 5nw5 (A) 951 1140 10.00 0 0.03 0.322867 -0.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132622)

Species Accession Gene Product
Echinococcus granulosus EgrG_000839300   p2X purinoceptor 4
Echinococcus granulosus EgrG_000815100   p2X purinoceptor 4
Echinococcus granulosus EgrG_000977600   p2X purinoceptor 4
Echinococcus multilocularis EmuJ_000977600   p2X purinoceptor 4
Echinococcus multilocularis EmuJ_000839300   p2X purinoceptor 4
Echinococcus multilocularis EmuJ_000815100   p2X purinoceptor 4
Homo sapiens ENSG00000108405   purinergic receptor P2X, ligand-gated ion channel, 1
Homo sapiens ENSG00000135124   purinergic receptor P2X, ligand-gated ion channel, 4
Mus musculus ENSMUSG00000020787   purinergic receptor P2X, ligand-gated ion channel, 1
Mus musculus ENSMUSG00000029470   purinergic receptor P2X, ligand-gated ion channel 4
Schistosoma japonicum Sjp_0017180   ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative
Schistosoma japonicum Sjp_0017170   ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative
Schistosoma mansoni Smp_176860   P2X receptor subunit
Schistosoma mansoni Smp_099640   P2X receptor subunit
Schmidtea mediterranea mk4.020589.00  
Schmidtea mediterranea mk4.025532.01   P2X purinoceptor
Schmidtea mediterranea mk4.029521.00   P2X purinoceptor
Schmidtea mediterranea mk4.014493.01  
Schmidtea mediterranea mk4.000231.02  
Schmidtea mediterranea mk4.008523.00  
Schmidtea mediterranea mk4.018055.00   P2X purinoceptor
Schmidtea mediterranea mk4.021255.00  
Schmidtea mediterranea mk4.025682.01  
Schmidtea mediterranea mk4.020610.01  
Schmidtea mediterranea mk4.000819.03  
Schmidtea mediterranea mk4.016722.00  
Schmidtea mediterranea mk4.027621.00   P2X purinoceptor
Schmidtea mediterranea mk4.021869.01   P2X purinoceptor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 4 Compounds References
Mus musculus purinergic receptor P2X, ligand-gated ion channel, 1 Compounds References
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 Compounds References
Rattus norvegicus P2X purinoceptor 4 Compounds References
Mus musculus purinergic receptor P2X, ligand-gated ion channel 4 Compounds References
Rattus norvegicus P2X purinoceptor 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus P2X purinoceptor 6 379 aa 36.9% 377 aa Compounds References
Canis lupus familiaris P2X7 purinoceptor 205 aa 38.5% 195 aa Compounds References
Rattus norvegicus P2X purinoceptor 5 455 aa 41.5% 402 aa Compounds References
Rattus norvegicus P2X purinoceptor 3 397 aa 40.3% 375 aa Compounds References
Rattus norvegicus P2X2/P2X3 receptor 397 aa 40.3% 375 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0017180 (Schistosoma japonicum), ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative
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