Detailed view for Sjp_0204150

Basic information

TDR Targets ID: 971529
Schistosoma japonicum, ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative
Source Database / ID:  Wormbase Parasite  

pI: 6.5773 | Length (AA): 326 | MW (Da): 35054 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00459   Inositol monophosphatase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0046854   phosphoinositide phosphorylation  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131693)

Species Accession Gene Product
Brugia malayi Bm1_41990   Inositol monophosphatase family protein
Caenorhabditis elegans CELE_ZK430.2   Protein TAG-231
Dictyostelium discoideum DDB_G0275663   3',5'-bisphosphate nucleotidase 1
Drosophila melanogaster Dmel_CG7789   CG7789 gene product from transcript CG7789-RA
Echinococcus granulosus EgrG_000670100   3'2'5' bisphosphate nucleotidase 1
Entamoeba histolytica EHI_179820   3(2),5-bisphosphate nucleotidase, putative
Echinococcus multilocularis EmuJ_000670100   3'(2'),5' bisphosphate nucleotidase 1
Homo sapiens ENSG00000162813   3'(2'), 5'-bisphosphate nucleotidase 1
Loa Loa (eye worm) LOAG_05255   hypothetical protein
Mus musculus ENSMUSG00000026617   bisphosphate 3'-nucleotidase 1
Schistosoma japonicum Sjp_0204150   ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative
Schistosoma mansoni Smp_008320   pap-inositol-14-phosphatase
Schmidtea mediterranea mk4.013688.00   3'(2'),5'-bisphosphate nucleotidase 1
Schmidtea mediterranea mk4.021372.00   3'(2'),5'-bisphosphate nucleotidase 1
Schmidtea mediterranea mk4.024877.00   3'(2'),5'-bisphosphate nucleotidase 1
Schmidtea mediterranea mk4.041504.00   3'(2'),5'-bisphosphate nucleotidase 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Inositol monophosphatase 1 277 aa 21.5% 275 aa Compounds References
Bos taurus Inositol-1(or 4)-monophosphatase 1 277 aa 21.5% 284 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0204150 (Schistosoma japonicum), ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative
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