Detailed view for Sjp_0069910

Basic information

TDR Targets ID: 971888
Schistosoma japonicum, ko:K04429 thousand and one amino acid protein kinase, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.5166 | Length (AA): 1088 | MW (Da): 122823 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 277 1u5q (A) 12 319 53.00 0 1 0.61911 -0.35
23 262 3a7i (A) 19 298 45.00 0 1 0.521591 -0.12
25 343 4ysj (A) 21 378 30.00 0.0000000055 1 0.292268 0.7
65 240 2rku (A) 134 307 31.00 0.000000093 1 0.530713 -0.9
104 233 4jrn (A) 406 526 37.00 0.041 0.11 0.142395 1.17
776 1025 4tql (A) 15 231 19.00 0 0.96 0.249791 -0.56
787 1003 5cwo (A) 4 220 12.00 0 0.03 0.291432 -1.01
825 1037 1jad (A) 13 212 27.00 0.013 0.56 0.409752 -0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129521)

Species Accession Gene Product
Brugia malayi Bm1_55590   Serine/threonine-protein kinase SULU
Brugia malayi Bm1_57415   hypothetical protein
Caenorhabditis elegans CELE_T17E9.1   Protein KIN-18, isoform A
Drosophila melanogaster Dmel_CG14217   CG14217 gene product from transcript CG14217-RF
Echinococcus granulosus EgrG_001094600   serine:threonine protein kinase TAO1
Echinococcus multilocularis EmuJ_001094600   serine:threonine protein kinase TAO1
Homo sapiens ENSG00000149930   TAO kinase 2
Homo sapiens ENSG00000135090   TAO kinase 3
Homo sapiens ENSG00000160551   TAO kinase 1
Loa Loa (eye worm) LOAG_02983   STE/STE20/TAO protein kinase
Mus musculus ENSMUSG00000059981   TAO kinase 2
Mus musculus ENSMUSG00000061288   TAO kinase 3
Mus musculus ENSMUSG00000017291   TAO kinase 1
Schistosoma japonicum Sjp_0069910   ko:K04429 thousand and one amino acid protein kinase, putative
Schistosoma mansoni Smp_068060.1   serine/threonine protein kinase
Schmidtea mediterranea mk4.027126.00  
Schmidtea mediterranea mk4.004610.05   Serine/threonine-protein kinase SULU
Schmidtea mediterranea mk4.008936.01  
Schmidtea mediterranea mk4.023185.00  
Schmidtea mediterranea mk4.024895.00   Serine/threonine-protein kinase SULU
Schmidtea mediterranea mk4.005348.00  
Schmidtea mediterranea mk4.005765.00   Serine/threonine-protein kinase TAO2

Essentiality

Sjp_0069910 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T17E9.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T17E9.1 Caenorhabditis elegans larval lethal wormbase
CELE_T17E9.1 Caenorhabditis elegans slow growth wormbase
CELE_T17E9.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens TAO kinase 1 Compounds References
Homo sapiens TAO kinase 2 Compounds References
Homo sapiens TAO kinase 3 Compounds References
Caenorhabditis elegans Protein KIN-18, isoform A Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis Aurora kinase B-A 361 aa 26.6% 290 aa Compounds References
Patiria pectinifera Cdc2 300 aa 22.6% 296 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0069910 (Schistosoma japonicum), ko:K04429 thousand and one amino acid protein kinase, putative
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