Detailed view for Sjp_0070630

Basic information

TDR Targets ID: 971895
Schistosoma japonicum, ko:K03307 solute:Na+ symporter, SSS family, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.0098 | Length (AA): 677 | MW (Da): 74748 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 9

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00474   Sodium:solute symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016020   membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 500 2xq2 (A) 9 454 27.00 0 1 0.719766 0.6
6 500 2xq2 (A) 11 454 29.00 0 1 0.730033 0.56
187 220 3bog (C) 3 69 99.99 0 0 1.06306 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127197)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG42235   CG42235 gene product from transcript CG42235-RE
Escherichia coli b3679   putative transporter
Echinococcus granulosus EgrG_000951000   sodium:glucose cotransporter 2
Echinococcus granulosus EgrG_000714050   solute carrier family 5
Echinococcus granulosus EgrG_001173900   sodium:myo inositol cotransporter
Echinococcus granulosus EgrG_000714000   sodium:glucose cotransporter
Echinococcus multilocularis EmuJ_000951000   sodium:glucose cotransporter 2
Echinococcus multilocularis EmuJ_000714000   solute carrier family 5
Echinococcus multilocularis EmuJ_001173900   sodium:myo inositol cotransporter
Homo sapiens ENSG00000140675   solute carrier family 5 (sodium/glucose cotransporter), member 2
Homo sapiens ENSG00000100191   solute carrier family 5 (glucose activated ion channel), member 4
Homo sapiens ENSG00000198743   solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
Homo sapiens ENSG00000100170   solute carrier family 5 (sodium/glucose cotransporter), member 1
Homo sapiens ENSG00000117834   solute carrier family 5 (sodium/sugar cotransporter), member 9
Homo sapiens ENSG00000154025   solute carrier family 5 (sodium/sugar cotransporter), member 10
Homo sapiens ENSG00000158865   solute carrier family 5 (sodium/inositol cotransporter), member 11
Mus musculus ENSMUSG00000011034   solute carrier family 5 (sodium/glucose cotransporter), member 1
Mus musculus ENSMUSG00000030781   solute carrier family 5 (sodium/glucose cotransporter), member 2
Mus musculus 64454   solute carrier family 5 (neutral amino acid transporters, system A), member 4b
Mus musculus ENSMUSG00000033255   predicted gene 5134
Mus musculus ENSMUSG00000030769   solute carrier family 5 (sodium/glucose cotransporter), member 11
Mus musculus ENSMUSG00000042371   solute carrier family 5 (sodium/glucose cotransporter), member 10
Mus musculus ENSMUSG00000020229   solute carrier family 5, member 4a
Mus musculus ENSMUSG00000028544   solute carrier family 5 (sodium/glucose cotransporter), member 9
Mus musculus ENSMUSG00000089774   solute carrier family 5 (inositol transporters), member 3
Schistosoma japonicum Sjp_0020360   Sodium/myo-inositol cotransporter, putative
Schistosoma japonicum Sjp_0070630   ko:K03307 solute:Na+ symporter, SSS family, putative
Schistosoma japonicum Sjp_0310080   expressed protein
Schistosoma mansoni Smp_134080   inositol transporter
Schistosoma mansoni Smp_134070   inositol transporter
Schmidtea mediterranea mk4.006081.00  
Schmidtea mediterranea mk4.001839.03  
Schmidtea mediterranea mk4.037618.00  
Schmidtea mediterranea mk4.001839.02  
Schmidtea mediterranea mk4.015373.00  

Essentiality

Sjp_0070630 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3679 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 5 (sodium/inositol cotransporter), member 11 Compounds References
Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 2 Compounds References
Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 1 Compounds References
Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 Compounds References
Rattus norvegicus Sodium/glucose cotransporter 2 Compounds References
Homo sapiens solute carrier family 5 (glucose activated ion channel), member 4 Compounds References
Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 1 Compounds References
Rattus norvegicus Sodium/glucose cotransporter 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Sjp_0070630 (Schistosoma japonicum), ko:K03307 solute:Na+ symporter, SSS family, putative
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