Detailed view for Sjp_0043500

Basic information

TDR Targets ID: 971933
Schistosoma japonicum, ko:K06112 membrane-associated guanylate kinase-related, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.3563 | Length (AA): 1368 | MW (Da): 148272 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF00625   Guanylate kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Rap1 signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 17 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 137 1uez (A) 11 90 21.00 0.0022 0.88 0.106958 0.29
41 139 1wi2 (A) 18 98 14.00 0.28 0.26 -0.0645786 0.6
179 236 2j41 (A) 34 91 41.00 0 0.64 0.528729 -0.64
186 232 1s96 (A) 40 86 45.00 0.056 0.57 0.561882 -0.3
456 489 1wmv (A) 12 49 56.00 0.017 0.42 0.502372 0.05
456 486 2ho2 (A) 255 284 50.00 0 0.39 0.497977 -0.21
546 658 2kpk (A) 9 119 52.00 0 1 0.774163 -0.91
750 835 3soe (A) 596 681 41.00 0 1 0.665211 -1.44
1073 1267 3gsl (A) 66 243 28.00 0.000000019 1 0.315148 0.18
1159 1269 1nf3 (C) 145 248 25.00 0 0.81 0.4005 -1.07
1165 1268 3r68 (A) 237 320 39.00 0.0035 0.97 0.308579 -0.15
1168 1294 1p1d (A) 23 142 33.00 0.00017 1 0.359404 -0.06
1171 1269 1uew (A) 13 101 39.00 0.00000022 1 0.517921 -0.75
1203 1275 4q3h (A) 167 238 35.00 0.013 0.97 0.548902 -0.68
1214 1270 1ihj (A) 49 105 39.00 0 1 0.484997 -0.05
1214 1274 1uf1 (A) 49 112 48.00 0.00054 0.99 0.497123 0.07
1320 1364 2fcf (A) 1199 1243 16.00 0.015 0.18 0.0629188 1.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129479)

Species Accession Gene Product
Brugia malayi Bm1_27395   PDZ domain containing protein
Caenorhabditis elegans CELE_K01A6.2   Protein MAGI-1, isoform A
Drosophila melanogaster Dmel_CG30388   CG30388 gene product from transcript CG30388-RA
Echinococcus granulosus EgrG_000388700   3'partial|membrane associated guanylate kinase ww and pdz
Echinococcus granulosus EgrG_001067700   membrane associated guanylate kinase ww and pdz
Echinococcus granulosus EgrG_002065200   membrane associated guanylate kinase, WW and PDZ
Echinococcus granulosus EgrG_000194900   membrane associated guanylate kinase ww and pdz
Echinococcus multilocularis EmuJ_000388700   membrane associated guanylate kinase ww and pdz
Echinococcus multilocularis EmuJ_000194900   membrane associated guanylate kinase, WW and PDZ
Echinococcus multilocularis EmuJ_001067700  
Homo sapiens ENSG00000187391   membrane associated guanylate kinase, WW and PDZ domain containing 2
Homo sapiens ENSG00000151276   membrane associated guanylate kinase, WW and PDZ domain containing 1
Homo sapiens ENSG00000081026   membrane associated guanylate kinase, WW and PDZ domain containing 3
Loa Loa (eye worm) LOAG_05231   hypothetical protein
Loa Loa (eye worm) LOAG_06884   hypothetical protein
Mus musculus ENSMUSG00000045095   membrane associated guanylate kinase, WW and PDZ domain containing 1
Mus musculus ENSMUSG00000052539   membrane associated guanylate kinase, WW and PDZ domain containing 3
Mus musculus ENSMUSG00000040003   membrane associated guanylate kinase, WW and PDZ domain containing 2
Schistosoma japonicum Sjp_0043500   ko:K06112 membrane-associated guanylate kinase-related, putative
Schistosoma mansoni Smp_141790   membrane associated guanylate kinase inverted related
Schistosoma mansoni Smp_132600   membrane associated guanylate kinase inverted related
Schmidtea mediterranea mk4.039583.00  
Schmidtea mediterranea mk4.000668.09  
Schmidtea mediterranea mk4.022411.00  
Schmidtea mediterranea mk4.031292.00  
Schmidtea mediterranea mk4.020773.00  
Schmidtea mediterranea mk4.020773.01   Membrane associated guanylate kinase inverted related
Schmidtea mediterranea mk4.000668.06  
Schmidtea mediterranea mk4.027987.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0043500 (Schistosoma japonicum), ko:K06112 membrane-associated guanylate kinase-related, putative
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