Detailed view for PF3D7_0821700

Basic information

TDR Targets ID: 972
Plasmodium falciparum, 60S ribosomal protein L22, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.8548 | Length (AA): 139 | MW (Da): 16382 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01776   Ribosomal L22e protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127156)

Species Accession Gene Product
Arabidopsis thaliana AT5G27770   60S ribosomal protein L22-3
Arabidopsis thaliana AT1G02830   large subunit ribosomal protein L22e
Arabidopsis thaliana AT3G05560   60S ribosomal protein L22-2
Babesia bovis BBOV_II001860   60S ribosomal L22e protein, putative
Brugia malayi Bm1_29390   60S ribosomal protein L22
Brugia malayi Bm1_29385   60S ribosomal protein L22
Caenorhabditis elegans CELE_C27A2.2   Protein RPL-22, isoform B
Cryptosporidium hominis Chro.70277   ribosomal protein L22
Cryptosporidium parvum cgd7_2420   60S ribosomal protein L22
Dictyostelium discoideum DDB_G0290091   S60 ribosomal protein L22
Dictyostelium discoideum DDB_G0288101   S60 ribosomal protein L22
Drosophila melanogaster Dmel_CG9871   Ribosomal protein L22-like
Drosophila melanogaster Dmel_CG7434   Ribosomal protein L22
Echinococcus granulosus EgrG_000888200   60S ribosomal protein L22
Entamoeba histolytica EHI_141940   hypothetical protein
Echinococcus multilocularis EmuJ_000888200   60S ribosomal protein L22
Giardia lamblia GL50803_16044   Hypothetical protein
Homo sapiens ENSG00000116251   ribosomal protein L22
Homo sapiens ENSG00000163584   ribosomal protein L22-like 1
Leishmania braziliensis LbrM.35.3500   60S ribosomal protein L22, putative
Leishmania braziliensis LbrM.35.4660   60S ribosomal protein L22, putative
Leishmania donovani LdBPK_363430.1   60S ribosomal protein L22, putative
Leishmania infantum LinJ.36.3430   60S ribosomal protein L22, putative
Leishmania infantum LinJ.36.4640   60S ribosomal protein L22, putative
Leishmania major LmjF.36.4420   60S ribosomal protein L22, putative
Leishmania major LmjF.36.3270   60S ribosomal protein L22, putative
Leishmania mexicana LmxM.36.4420   60S ribosomal protein L22, putative
Loa Loa (eye worm) LOAG_14782   60S ribosomal protein L22
Mus musculus 669393   predicted gene 9457
Mus musculus 102642602   60S ribosomal protein L22-like
Mus musculus ENSMUSG00000028936   ribosomal protein L22
Mus musculus ENSMUSG00000039221   ribosomal protein L22 like 1
Neospora caninum NCLIV_016380   Ribosomal protein L22, related
Oryza sativa 4332802   Os03g0343500
Oryza sativa 4344261   Os07g0674200
Onchocerca volvulus OVOC238   60S ribosomal protein L22 homolog
Onchocerca volvulus OVOC239   60S ribosomal protein L22 homolog
Plasmodium berghei PBANKA_0709100   60S ribosomal protein L22, putative
Plasmodium falciparum PF3D7_0821700   60S ribosomal protein L22, putative
Plasmodium knowlesi PKNH_1315700   60S ribosomal protein L22, putative
Plasmodium vivax PVX_089280   60S ribosomal protein L22, putative
Plasmodium yoelii PY04247   ribosomal protein L22-related
Saccharomyces cerevisiae YFL034C-A   ribosomal 60S subunit protein L22B
Saccharomyces cerevisiae YLR061W   ribosomal 60S subunit protein L22A
Schistosoma japonicum Sjp_0020810   ko:K02891 large subunit ribosomal protein L22e, putative
Schistosoma mansoni Smp_085300   60S ribosomal protein L22
Schmidtea mediterranea mk4.040351.01   60S ribosomal protein L22, putative
Trypanosoma brucei gambiense Tbg972.11.11410   60S ribosomal protein L22, putative
Trypanosoma brucei gambiense Tbg972.10.11970   60S ribosomal protein L22, putative
Trypanosoma brucei Tb427tmp.01.1920   60S ribosomal protein L22, putative
Trypanosoma brucei Tb927.10.9800   60S ribosomal protein L22
Trypanosoma cruzi TcCLB.504147.120   60S ribosomal protein L22, putative
Trypanosoma cruzi TcCLB.510719.160   60S ribosomal protein L22, putative
Trypanosoma cruzi TcCLB.509747.20   60S ribosomal protein L22, putative
Toxoplasma gondii TGME49_239760   ribosomal protein RPL22
Theileria parva TP04_0394   60S ribosomal protein L22, putative
Trichomonas vaginalis TVAG_225760   60S ribosomal protein L22, putative
Trichomonas vaginalis TVAG_190130   60S ribosomal protein L22, putative
Trichomonas vaginalis TVAG_057020   60S ribosomal protein L22, putative
Trichomonas vaginalis TVAG_121380   60S ribosomal protein L22, putative
Trichomonas vaginalis TVAG_140190   60S ribosomal protein L22, putative

Essentiality

PF3D7_0821700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.1920 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.1920 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.1920 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.1920 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.9800 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.9800 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.9800 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.9800 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C27A2.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C27A2.2 Caenorhabditis elegans larval arrest wormbase
CELE_C27A2.2 Caenorhabditis elegans slow growth wormbase
CELE_C27A2.2 Caenorhabditis elegans sterile wormbase
PBANKA_0709100 Plasmodium berghei Essential plasmo
TGME49_239760 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0821700 (Plasmodium falciparum), 60S ribosomal protein L22, putative
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