Detailed view for Sjp_0214550

Basic information

TDR Targets ID: 972052
Schistosoma japonicum, ko:K04136 adrenergic receptor, alpha 1b, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.3109 | Length (AA): 497 | MW (Da): 57639 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133042)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG33976   Octopamine beta2 receptor
Drosophila melanogaster Dmel_CG6919   Octopamine beta1 receptor
Homo sapiens ENSG00000164270   5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Mus musculus ENSMUSG00000026322   5 hydroxytryptamine (serotonin) receptor 4
Schistosoma japonicum Sjp_0214550   ko:K04136 adrenergic receptor, alpha 1b, putative
Schmidtea mediterranea mk4.003002.02   5-hydroxytryptamine receptor 4
Schmidtea mediterranea mk4.005562.01   5-hydroxytryptamine receptor 4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Serotonin 4 (5-HT4) receptor Compounds References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor Compounds References
Mus musculus 5 hydroxytryptamine (serotonin) receptor 4 Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 28.2% 380 aa Compounds References
Cavia porcellus Cholecystokinin A receptor 430 aa 26.4% 375 aa Compounds References
Sus scrofa Dopamine D1 receptor 446 aa 35.2% 364 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 30.2% 374 aa Compounds References
Macaca mulatta Beta-3 adrenergic receptor 418 aa 28.8% 379 aa Compounds References
Cavia porcellus Adenosine A2a receptor 409 aa 24.7% 380 aa Compounds References
Rattus norvegicus Serotonin 2a (5-HT2a) receptor 471 aa 27.5% 422 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 25.5% 55 aa Compounds References
Chlorocebus aethiops Dopamine D3 receptor 400 aa 29.6% 395 aa Compounds References
Oryctolagus cuniculus Uncharacterized protein 460 aa 23.4% 462 aa Compounds References
Rattus norvegicus Vasopressin V1a receptor 424 aa 21.8% 400 aa Compounds References
Macaca fascicularis G-protein coupled receptor 119 335 aa 22.1% 384 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 27.4% 405 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 32.5% 381 aa Compounds References
Rattus norvegicus Orexin receptor 2 460 aa 22.3% 408 aa Compounds References
Bos taurus Serotonin 2a (5-HT2a) receptor 470 aa 28.7% 418 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 29.3% 362 aa Compounds References
Sus scrofa Serotonin 2a (5-HT2a) receptor 470 aa 28.0% 422 aa Compounds References
Rattus norvegicus Dopamine D2 receptor 444 aa 30.0% 440 aa Compounds References
Rattus norvegicus Adenosine A2a receptor 410 aa 25.4% 366 aa Compounds References
Oryctolagus cuniculus Alpha-1a adrenergic receptor 466 aa 31.1% 395 aa Compounds References
Sus scrofa Alpha-2a adrenergic receptor 450 aa 29.4% 428 aa Compounds References
Bos taurus Dopamine D1 receptor 446 aa 34.5% 371 aa Compounds References
Bos taurus Alpha-1a adrenergic receptor 466 aa 29.3% 447 aa Compounds References
Rattus norvegicus Dopamine receptor 475 aa 33.3% 405 aa Compounds References
Bos taurus Dopamine receptor 446 aa 34.5% 371 aa Compounds References
Rattus norvegicus Cholecystokinin A receptor 444 aa 24.8% 379 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 33.9% 384 aa Compounds References
Sus scrofa Alpha-1A adrenergic receptor 466 aa 30.3% 432 aa Compounds References
Rattus norvegicus Alpha-2c adrenergic receptor 458 aa 28.3% 421 aa Compounds References
Rattus norvegicus Dopamine D5 receptor 475 aa 33.3% 405 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 33.1% 366 aa Compounds References
Canis lupus familiaris Cholecystokinin B receptor 453 aa 21.2% 392 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 29.7% 417 aa Compounds References
Cavia porcellus Serotonin 7 (5-HT7) receptor 446 aa 32.6% 362 aa Compounds References
Rattus norvegicus Cholecystokinin receptor 444 aa 24.8% 379 aa Compounds References
Rattus norvegicus Serotonin 2 (5-HT2) receptor 460 aa 28.3% 427 aa Compounds References
Canis familiaris 5-hydroxytryptamine receptor 2C 458 aa 28.0% 403 aa Compounds References
Rattus norvegicus Adenosine A2 receptor 410 aa 25.4% 366 aa Compounds References
Rattus norvegicus Orexin receptor 1 416 aa 22.1% 376 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 29.7% 417 aa Compounds References
Cavia porcellus Histamine H4 receptor 389 aa 26.5% 396 aa Compounds References
Rattus norvegicus Beta-2 adrenergic receptor 418 aa 32.6% 396 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 29.1% 392 aa Compounds References
Canis lupus familiaris Beta-3 adrenergic receptor 405 aa 30.9% 349 aa Compounds References
Rattus norvegicus Alpha-1a adrenergic receptor 466 aa 31.6% 386 aa Compounds References
Canis lupus familiaris Uncharacterized protein 335 aa 20.2% 307 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 29.2% 356 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 37.0% 100 aa Compounds References
Mesocricetus auratus Beta-2 adrenergic receptor 418 aa 32.5% 381 aa Compounds References
Rattus norvegicus Serotonin 7 (5-HT7) receptor 448 aa 32.3% 362 aa Compounds References
Bos taurus Uncharacterized protein 403 aa 24.2% 364 aa Compounds References
Rattus norvegicus Dopamine D1 receptor 446 aa 35.2% 366 aa Compounds References
Chlorocebus aethiops Dopamine D2 receptor 443 aa 30.2% 440 aa Compounds References
Canis lupus familiaris 5-hydroxytryptamine receptor 2A 470 aa 29.3% 389 aa Compounds References
Bos taurus Beta-2 adrenergic receptor 418 aa 32.2% 366 aa Compounds References
Rattus norvegicus Muscarinic acetylcholine receptor M1 460 aa 23.4% 462 aa Compounds References
Rattus norvegicus Dopamine D4 receptor 387 aa 28.7% 373 aa Compounds References
Rattus norvegicus Serotonin 2c (5-HT2c) receptor 460 aa 28.3% 427 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 422 aa 28.3% 459 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 29.3% 362 aa Compounds References
Rattus norvegicus Histamine H4 receptor 391 aa 26.2% 401 aa Compounds References
Microtus ochrogaster Vasopressin V1a receptor 420 aa 20.7% 405 aa Compounds References
Bos taurus Cholecystokinin B receptor 454 aa 20.7% 381 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 31.7% 334 aa Compounds References
Bos taurus Rhodopsin 348 aa 20.4% 304 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 29.2% 356 aa Compounds References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor 422 aa 29.3% 444 aa Compounds References
Canis lupus familiaris Dopamine D2 receptor 443 aa 30.1% 439 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 26.1% 364 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 29.2% 356 aa Compounds References
Bos taurus Dopamine D2 receptor 444 aa 29.9% 438 aa Compounds References
Rattus norvegicus Glucose-dependent insulinotropic receptor 468 aa 21.4% 383 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Sjp_0214550 (Schistosoma japonicum), ko:K04136 adrenergic receptor, alpha 1b, putative
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