Detailed view for Sjp_0201950
Basic information
Schistosoma japonicum, ko:K01206 alpha-L-fucosidase [EC3.2.1.51], putative
Source Database / ID: Wormbase Parasite
pI: 7.338 |
Length (AA): 452 |
MW (Da): 52632 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0005975 carbohydrate metabolic process
GO:0006004 fucose metabolic process
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_129683)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_37265 | Alpha-L-fucosidase family protein |
| Caenorhabditis elegans | CELE_W03G11.3 | Protein W03G11.3 |
| Dictyostelium discoideum | DDB_G0274391 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0276661 | hypothetical protein |
| Drosophila melanogaster | Dmel_CG6128 | alpha-L-fucosidase |
| Echinococcus granulosus | EgrG_000618900 | fucosidase alpha L 1 tissue |
| Echinococcus multilocularis | EmuJ_000618900 | fucosidase, alpha L 1, tissue |
| Homo sapiens | ENSG00000001036 | fucosidase, alpha-L- 2, plasma |
| Homo sapiens | ENSG00000179163 | fucosidase, alpha-L- 1, tissue |
| Loa Loa (eye worm) | LOAG_04875 | alpha-L-fucosidase |
| Mus musculus | ENSMUSG00000028673 | fucosidase, alpha-L- 1, tissue |
| Mus musculus | 66848 | fucosidase, alpha-L- 2, plasma |
| Mycobacterium ulcerans | MUL_2911 | alpha-L-fucosidase |
| Schistosoma japonicum | Sjp_0201950 | ko:K01206 alpha-L-fucosidase [EC3.2.1.51], putative |
| Schistosoma mansoni | Smp_146250 | alpha-l-fucosidase |
| Schmidtea mediterranea | mk4.010223.00 | |
| Schmidtea mediterranea | mk4.002271.05 | Tissue alpha-L-fucosidase |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Rattus norvegicus | Alpha-L-fucosidase I | Compounds | References |
| Homo sapiens | fucosidase, alpha-L- 2, plasma | Compounds | References |
| Bos taurus | Alpha-L-fucosidase 1 | Compounds | References |
| Homo sapiens | fucosidase, alpha-L- 1, tissue | Compounds | References |
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References