Detailed view for Sjp_0015690

Basic information

TDR Targets ID: 972279
Schistosoma japonicum, ko:K01050 cholinesterase [EC3.1.1.8], putative
Source Database / ID:  Wormbase Parasite  

pI: 6.8119 | Length (AA): 596 | MW (Da): 67628 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00135   Carboxylesterase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0004104   cholinesterase activity  

Metabolic Pathways

Glycerophospholipid metabolism (KEGG)
Cholinergic synapse (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 595 3be8 (A) 0 534 27.00 0.0000000028 1 1.07801 0.41
28 595 6emi (A) 4 478 45.00 0 1 1.29922 -0.25
133 268 3ain (A) 41 175 26.00 0.034 0.92 0.476171 -0.56
147 256 1jji (A) 72 173 29.00 0.0075 0.93 0.506474 -0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_176990)

Species Accession Gene Product
Echinococcus granulosus EgrG_000297300   BC026374 protein S09 family
Echinococcus multilocularis EmuJ_000297300   BC026374 protein (S09 family)
Schistosoma japonicum Sjp_0015680   expressed protein
Schistosoma japonicum Sjp_0015690   ko:K01050 cholinesterase [EC3.1.1.8], putative
Schistosoma mansoni Smp_125350   BC026374 protein (S09 family)
Schmidtea mediterranea mk4.015657.00  
Schmidtea mediterranea mk4.000742.12  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Laodelphax striatella Acetylcholinesterase 426 aa 34.1% 417 aa Compounds References
Sus scrofa Carboxylesterase 566 aa 31.7% 581 aa Compounds References
Equus caballus Cholinesterase 574 aa 36.9% 577 aa Compounds References
Rattus norvegicus Liver carboxylesterase B-1 561 aa 31.0% 574 aa Compounds References
Torpedo californica Acetylcholinesterase 586 aa 33.6% 577 aa Compounds References
Oryctolagus cuniculus Acyl coenzyme A:cholesterol acyltransferase 565 aa 30.0% 574 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Sjp_0015690 (Schistosoma japonicum), ko:K01050 cholinesterase [EC3.1.1.8], putative
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