Detailed view for Sjp_0089570

Basic information

TDR Targets ID: 972865
Schistosoma japonicum, ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative
Source Database / ID:  Wormbase Parasite  

pI: 6.9007 | Length (AA): 1723 | MW (Da): 193798 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00130   Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00780   CNH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 415 4aw2 (A) 6 414 53.00 0 1 0.816315 -0.77
7 416 5ote (A) 6 414 54.00 0 1 0.832895 -0.73
67 379 4lqq (D) 341 704 42.00 0 1 0.359165 0.81
79 681 4e3c (A) 16 648 18.00 0.0000000000066 1 0.320974 0.91
511 681 4uos (A) 10 183 11.00 0.063 0.02 0.264103 -1.51
804 854 4l9m (A) 541 591 37.00 0.00000053 0.81 0.397417 -0.05
1290 1660 4k6j (A) 716 1151 9.00 0 0 0.213847 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129617)

Species Accession Gene Product
Caenorhabditis elegans CELE_K08B12.5   Protein MRCK-1
Drosophila melanogaster Dmel_CG4012   genghis khan
Echinococcus granulosus EgrG_000212000   Serine/threonine-protein kinase Genghis Khan
Echinococcus multilocularis EmuJ_000212000   serine:threonine protein kinase MRCK beta
Homo sapiens ENSG00000198752   CDC42 binding protein kinase beta (DMPK-like)
Homo sapiens ENSG00000171219   CDC42 binding protein kinase gamma (DMPK-like)
Homo sapiens ENSG00000143776   CDC42 binding protein kinase alpha (DMPK-like)
Loa Loa (eye worm) LOAG_09020   AGC/DMPK/GEK protein kinase
Mus musculus ENSMUSG00000026490   CDC42 binding protein kinase alpha
Mus musculus ENSMUSG00000024769   CDC42 binding protein kinase gamma (DMPK-like)
Mus musculus ENSMUSG00000021279   CDC42 binding protein kinase beta
Schistosoma japonicum Sjp_0115790   expressed protein
Schistosoma japonicum Sjp_0089560   ko:K07117 SET and MYND domain containing 1a, putative
Schistosoma japonicum Sjp_0089570   ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative
Schistosoma japonicum Sjp_0304700   expressed protein
Schistosoma mansoni Smp_158560.2   serine/threonine protein kinase
Schistosoma mansoni Smp_158560.1   serine/threonine protein kinase
Schmidtea mediterranea mk4.001384.12   Serine/threonine-protein kinase Genghis Khan
Schmidtea mediterranea mk4.016719.00  
Schmidtea mediterranea mk4.005383.01  
Schmidtea mediterranea mk4.004877.00   Serine/threonine kinase

Essentiality

Sjp_0089570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K08B12.5 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens CDC42 binding protein kinase alpha (DMPK-like) Compounds References
Homo sapiens CDC42 binding protein kinase beta (DMPK-like) Compounds References
Homo sapiens CDC42 binding protein kinase gamma (DMPK-like) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 32.7% 333 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 32.7% 333 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.4% 316 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 21.7% 341 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 34.1% 311 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0089570 (Schistosoma japonicum), ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative
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