Detailed view for Sjp_0121320

Basic information

TDR Targets ID: 972906
Schistosoma japonicum, Glutamate receptor, ionotropic kainate 1 precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.5291 | Length (AA): 68 | MW (Da): 7598 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10613   Ligated ion channel L-glutamate- and glycine-binding site

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005234   extracellular-glutamate-gated ion channel activity  
GO:0004970   ionotropic glutamate receptor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 36 3gba (A) 73 106 56.00 0.0073 0.98 1.08166 0.74
3 36 5ikb (A) 73 106 50.00 0.000053 0.99 1.01766 0.79
3 67 3kg2 (A) 463 527 43.00 0.00000000008 0.26 1.23935 1.77
9 49 5dt6 (A) 86 132 61.00 0.000000016 0.13 0.89674 1.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127034)

Species Accession Gene Product
Arabidopsis thaliana AT2G17260   glutamate receptor
Arabidopsis thaliana AT2G32400   glutamate receptor 5
Arabidopsis thaliana AT2G32390   glutamate receptor 3.5
Arabidopsis thaliana AT1G42540   glutamate receptor 3.3
Arabidopsis thaliana AT1G05200   glutamate receptor 3.4
Arabidopsis thaliana AT3G51480   glutamate receptor 3.6
Arabidopsis thaliana AT4G35290   glutamate receptor 3.2
Caenorhabditis elegans CELE_C06A8.9   Protein GLR-4, isoform A
Caenorhabditis elegans CELE_K10D3.1   Protein GLR-3
Caenorhabditis elegans CELE_ZC196.7   Protein GLR-5
Drosophila melanogaster Dmel_CG11155   CG11155 gene product from transcript CG11155-RD
Drosophila melanogaster Dmel_CG8681   CG8681 gene product from transcript CG8681-RB
Drosophila melanogaster Dmel_CG5621   CG5621 gene product from transcript CG5621-RA
Drosophila melanogaster Dmel_CG31201   Glutamate receptor IIE
Drosophila melanogaster Dmel_CG9935   CG9935 gene product from transcript CG9935-RD
Drosophila melanogaster Dmel_CG3822   CG3822 gene product from transcript CG3822-RA
Drosophila melanogaster Dmel_CG18039   Glutamate receptor IID
Echinococcus granulosus EgrG_000499600   Glutamate receptor ionotropic kainate 2
Echinococcus granulosus EgrG_001066000   glutamate receptor ionotropic kainate
Echinococcus granulosus EgrG_000618700   Glutamate receptor ionotropic kainate 2
Echinococcus granulosus EgrG_000849400   glutamate receptor ionotropic kainate 3
Echinococcus granulosus EgrG_000499700   Glutamate receptor ionotropic kainate 2
Echinococcus multilocularis EmuJ_000007900   NMDA receptor
Echinococcus multilocularis EmuJ_001066000   glutamate receptor ionotropic kainate
Echinococcus multilocularis EmuJ_000499600   Glutamate receptor, ionotropic kainate 2
Echinococcus multilocularis EmuJ_000618700   Glutamate receptor, ionotropic kainate 2
Echinococcus multilocularis EmuJ_000499700   Glutamate receptor, ionotropic kainate 2
Echinococcus multilocularis EmuJ_000849400   Glutamate receptor, ionotropic kainate 3
Homo sapiens ENSG00000163873   glutamate receptor, ionotropic, kainate 3
Homo sapiens ENSG00000149403   glutamate receptor, ionotropic, kainate 4
Homo sapiens ENSG00000105737   glutamate receptor, ionotropic, kainate 5
Homo sapiens ENSG00000164418   glutamate receptor, ionotropic, kainate 2
Homo sapiens ENSG00000171189   glutamate receptor, ionotropic, kainate 1
Mus musculus ENSMUSG00000003378   glutamate receptor, ionotropic, kainate 5 (gamma 2)
Mus musculus ENSMUSG00000032017   glutamate receptor, ionotropic, kainate 4
Mus musculus ENSMUSG00000056073   glutamate receptor, ionotropic, kainate 2 (beta 2)
Mus musculus 14805   glutamate receptor, ionotropic, kainate 1
Mus musculus ENSMUSG00000001985   glutamate receptor, ionotropic, kainate 3
Oryza sativa 4328089   Os02g0117500
Oryza sativa 4341854   Os06g0680500
Oryza sativa 4342180   Os07g0103100
Oryza sativa 4343413   Os07g0522600
Schistosoma japonicum Sjp_0081970   expressed protein
Schistosoma japonicum Sjp_0121320   Glutamate receptor, ionotropic kainate 1 precursor, putative
Schistosoma japonicum Sjp_0087970   expressed protein
Schistosoma japonicum Sjp_0128710   Glutamate receptor, ionotropic kainate 3 precursor, putative
Schistosoma japonicum Sjp_0107720   Glutamate receptor delta-2 subunit precursor, putative
Schistosoma mansoni Smp_147430   glutamate receptor kainate
Schistosoma mansoni Smp_153780   glutamate receptor kainate
Schmidtea mediterranea mk4.009002.00  
Schmidtea mediterranea mk4.000574.09  
Schmidtea mediterranea mk4.012754.02   Putative glutamate receptor, kainate
Schmidtea mediterranea mk4.029042.00  
Schmidtea mediterranea mk4.000966.01  
Schmidtea mediterranea mk4.000966.00  
Schmidtea mediterranea mk4.010076.00   Putative glutamate receptor, kainate
Schmidtea mediterranea mk4.018463.00   Putative glutamate receptor, kainate
Schmidtea mediterranea mk4.019036.00  
Schmidtea mediterranea mk4.000335.04  
Schmidtea mediterranea mk4.013738.00   Putative glutamate receptor, kainate

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens glutamate receptor, ionotropic, kainate 2 Compounds References
Rattus norvegicus Glutamate receptor ionotropic kainate 5 Compounds References
Rattus norvegicus Glutamate receptor ionotropic kainate 4 Compounds References
Rattus norvegicus Glutamate receptor ionotropic kainate 3 Compounds References
Rattus norvegicus Glutamate receptor ionotropic kainate 1 Compounds References
Homo sapiens glutamate receptor, ionotropic, kainate 1 Compounds References
Rattus norvegicus Glutamate receptor ionotropic kainate 2 Compounds References
Xenopus laevis Glutamate receptor ionotropic kainate 2 Compounds References
Homo sapiens glutamate receptor, ionotropic, kainate 5 Compounds References
Homo sapiens glutamate receptor, ionotropic, kainate 3 Compounds References
Homo sapiens glutamate receptor, ionotropic, kainate 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0121320 (Schistosoma japonicum), Glutamate receptor, ionotropic kainate 1 precursor, putative
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