Detailed view for Sjp_0066950

Basic information

TDR Targets ID: 973007
Schistosoma japonicum, Neuronal acetylcholine receptor subunit alpha-3 precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 9.3275 | Length (AA): 1279 | MW (Da): 148681 | Paralog Number: 8

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF02931   Neurotransmitter-gated ion-channel ligand binding domain
PF02932   Neurotransmitter-gated ion-channel transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0034220   transmembrane ion transport  
GO:0022848   acetylcholine-gated cation channel activity  
GO:0045211   postsynaptic membrane  
GO:0016021   integral to membrane  
GO:0003676   nucleic acid binding  
GO:0005230   extracellular ligand-gated ion channel activity  
GO:0005216   ion channel activity  
GO:0004888   transmembrane receptor activity  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
45 130 1whx (A) 222 308 14.00 0 0.23 0.290249 -0.93
46 122 2fc8 (A) 17 97 27.00 0.83 1 0.495768 -1.29
141 212 1h6k (X) 40 115 24.00 0 0.96 0.452546 -0.81
182 225 2cq3 (A) 164 207 25.00 0.76 0.16 0.155539 1.23
248 281 3bog (C) 3 69 99.99 0 0 1.03389 -0.2
290 478 4afh (A) 1 188 27.00 0 1 0.474995 -0.29
817 1027 4uxu (A) 4 200 27.00 0.0000000022 1 0.412215 0.28
817 970 4afh (A) 7 154 39.00 0 0.93 0.323637 0.85
817 1027 2qc1 (B) 2 198 28.00 0.0000000027 0.86 0.415215 0.21
1258 1307 2ksr (A) 25 72 50.00 0.000049 0.08 0.270126 2.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_140937)

Species Accession Gene Product
Echinococcus granulosus EgrG_000591600   nAChR subunit
Echinococcus granulosus EgrG_000462600   neuronal acetylcholine receptor subunit alpha 4
Echinococcus granulosus EgrG_000707900   nAChR subunit ShAR1 beta2
Echinococcus multilocularis EmuJ_000462600   neuronal acetylcholine receptor subunit alpha 4
Echinococcus multilocularis EmuJ_000591600   nAChR subunit
Echinococcus multilocularis EmuJ_000707900   nAChR subunit (ShAR1 beta2)
Schistosoma japonicum Sjp_0066940   Acetylcholine receptor subunit alpha-type unc-38 precursor, putative
Schistosoma japonicum Sjp_0108290   Acetylcholine receptor subunit alpha-L1 precursor, putative
Schistosoma japonicum Sjp_0121370   IPR006201,Neurotransmitter-gated ion-channel;IPR006202,Neurotransmitter-gated ion-channel ligand-binding,domain-containing
Schistosoma japonicum Sjp_0302330   IPR000504,RNA-binding region RNP-1 (RNA recognition motif);IPR012677,Nucleotide-binding, alpha-beta plait,domain-containing
Schistosoma japonicum Sjp_0304300   expressed protein
Schistosoma japonicum Sjp_0080650   IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing
Schistosoma japonicum Sjp_0300850   ko:K04804 cholinergic receptor, nicotinic, alpha 2 (neuronal), putative
Schistosoma japonicum Sjp_0066950   Neuronal acetylcholine receptor subunit alpha-3 precursor, putative
Schistosoma japonicum Sjp_0097240   Neuronal acetylcholine receptor subunit alpha-7 precursor, putative
Schistosoma mansoni Smp_142700   nAChR subunit
Schistosoma mansoni Smp_132070.1   nAChR subunit
Schistosoma mansoni Smp_037960   nAChR subunit
Schistosoma mansoni Smp_157790   nAChR subunit
Schistosoma mansoni Smp_132070.2   nAChR subunit
Schistosoma mansoni Smp_142690   nAChR subunit (ShAR1-beta2-like)
Schmidtea mediterranea mk4.033395.00  
Schmidtea mediterranea mk4.010082.00  
Schmidtea mediterranea mk4.013388.00   Putative nachr subunit
Schmidtea mediterranea mk4.023568.00  
Schmidtea mediterranea mk4.009648.02   Nicotinic acetylcholine receptor beta 3
Schmidtea mediterranea mk4.002965.00  
Schmidtea mediterranea mk4.004894.00   Nicotinic acetylcholine receptor beta 3

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Neuronal acetylcholine receptor subunit alpha-3 499 aa 26.1% 514 aa Compounds References
Macaca mulatta Neuronal acetylcholine receptor subunit alpha-7 502 aa 24.2% 517 aa Compounds References
Rattus norvegicus Nicotinic acetylcholine receptor alpha6/alpha3/beta4 495 aa 23.4% 501 aa Compounds References
Rattus norvegicus Serotonin 3a (5-HT3a) receptor 483 aa 21.2% 505 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 495 aa 23.4% 501 aa Compounds References
Torpedo californica Acetylcholine receptor protein alpha chain 461 aa 26.1% 506 aa Compounds References
Rattus norvegicus Nicotinic acetylcholine receptor alpha9/alpha10 447 aa 23.4% 509 aa Compounds References
Rattus norvegicus Serotonin 3 (5-HT3) receptor 483 aa 21.2% 505 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-9 subunit 479 aa 26.0% 488 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor 452 aa 27.7% 364 aa Compounds References
Heliothis virescens Nicotinic acetylcholine receptor alpha1 subunit 523 aa 23.8% 484 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-2 subunit 511 aa 25.1% 495 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-10 subunit 447 aa 23.4% 509 aa Compounds References
Periplaneta americana Nicotinic acetylcholine receptor alpha8 subunit 538 aa 23.3% 502 aa Compounds References
Myzus persicae Nicotinic acetylcholine receptor 509 aa 25.4% 516 aa Compounds References
Aplysia californica Soluble acetylcholine receptor 236 aa 22.5% 204 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 495 aa 23.4% 501 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit 502 aa 24.9% 518 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 499 aa 26.1% 514 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor subunit beta-4 495 aa 23.4% 501 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0066950 (Schistosoma japonicum), Neuronal acetylcholine receptor subunit alpha-3 precursor, putative
Title for this comment
Comment