Detailed view for Sjp_0065920

Basic information

TDR Targets ID: 973395
Schistosoma japonicum, ko:K08837 serine/threonine kinase 10, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.1827 | Length (AA): 837 | MW (Da): 94793 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 212 6eim (A) 108 317 56.00 0 1 0.787004 -0.64
1 200 4u3y (A) 103 302 45.00 0 1 0.712147 -1.23
1 340 3hx4 (A) 126 474 22.00 0 1 0.42081 0.3
264 297 3bog (C) 3 69 99.99 0 0 1.02106 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130670)

Species Accession Gene Product
Brugia malayi Bm1_26435   Protein kinase domain containing protein
Caenorhabditis elegans CELE_C04A11.3   Protein GCK-4
Dictyostelium discoideum DDB_G0267730   STE20 family protein kinase
Drosophila melanogaster Dmel_CG4527   Sterile20-like kinase
Echinococcus granulosus EgrG_001193000   STE20 serine:threonine protein kinase
Echinococcus multilocularis EmuJ_001193000   STE20 serine:threonine protein kinase
Homo sapiens ENSG00000072786   serine/threonine kinase 10
Homo sapiens ENSG00000065613   STE20-like kinase
Loa Loa (eye worm) LOAG_06240   STE/STE20/SLK protein kinase
Loa Loa (eye worm) LOAG_04738   hypothetical protein
Mus musculus ENSMUSG00000025060   STE20-like kinase
Mus musculus ENSMUSG00000020272   serine/threonine kinase 10
Schistosoma japonicum Sjp_0065920   ko:K08837 serine/threonine kinase 10, putative
Schistosoma japonicum Sjp_0105200   expressed protein
Schistosoma mansoni Smp_150260   protein kinase
Schmidtea mediterranea mk4.001249.06   Protein kinase

Essentiality

Sjp_0065920 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C04A11.3 Caenorhabditis elegans larval arrest wormbase
CELE_C04A11.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus STE20-like kinase Compounds References
Homo sapiens STE20-like kinase Compounds References
Homo sapiens serine/threonine kinase 10 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0065920 (Schistosoma japonicum), ko:K08837 serine/threonine kinase 10, putative
Title for this comment
Comment