Detailed view for Sjp_0065500

Basic information

TDR Targets ID: 973445
Schistosoma japonicum, Proto-oncogene tyrosine-protein kinase FYN, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.9374 | Length (AA): 558 | MW (Da): 64047 | Paralog Number: 5

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03998   Utp11 protein
PF07714   Protein tyrosine kinase
PF12330   Haspin like kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0032040   small subunit processome  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004672   protein kinase activity  
GO:0006364   rRNA processing  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
37 495 1fmk (A) 91 526 40.00 0 1 1.10436 0.62
208 532 1koa (A) 5921 6237 20.00 0 1 0.707783 0.48
224 488 2dq7 (X) 1 263 54.00 0 1 1.18306 -0.95
227 490 4csv (A) 1 264 56.00 0 1 1.07827 -0.62
240 488 5da3 (A) 197 444 43.00 0 1 1.06134 -1.12
257 523 4ysj (A) 52 324 24.00 0 1 0.711354 -0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127750)

Species Accession Gene Product
Brugia malayi Bm1_36040   SRC-1
Brugia malayi Bm1_41725   protein-tyrosine kinase
Caenorhabditis elegans CELE_Y92H12A.1   Protein SRC-1
Caenorhabditis elegans CELE_F49B2.5   Protein SRC-2
Drosophila melanogaster Dmel_CG7524   Src oncogene at 64B
Drosophila melanogaster Dmel_CG44128   Src oncogene at 42A
Echinococcus granulosus EgrG_000580100   tyrosine kinase
Echinococcus granulosus EgrG_000579850   tyrosine kinase|tyrosine protein kinase Fyn
Echinococcus granulosus EgrG_000670400   proto oncogene tyrosine protein kinase LCK
Echinococcus granulosus EgrG_000598200   tyrosine protein kinase Src42A
Echinococcus granulosus EgrG_000515100   3'partial|tyrosine protein kinase Fgr
Echinococcus granulosus EgrG_000932000   tyrosine protein kinase Fyn
Echinococcus granulosus EgrG_000642300   tyrosine protein kinase Src64B
Echinococcus granulosus EgrG_000584700   tyrosine protein kinase Blk
Echinococcus granulosus EgrG_001125300   tyrosine protein kinase Fyn
Echinococcus granulosus EgrG_001116400   tyrosine protein kinase Src42A
Echinococcus granulosus EgrG_001155200   tyrosine protein kinase HCK
Echinococcus granulosus EgrG_000132100   tyrosine protein kinase Fyn
Echinococcus granulosus EgrG_000366500   tyrosine protein kinase Lyn
Entamoeba histolytica EHI_140330   protein kinase, putative
Echinococcus multilocularis EmuJ_000642300   tyrosine protein kinase Src64B
Echinococcus multilocularis EmuJ_000642200   tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase
Echinococcus multilocularis EmuJ_000580100   tyrosine protein kinase Fyn
Echinococcus multilocularis EmuJ_001125300   tyrosine protein kinase Fyn
Echinococcus multilocularis EmuJ_000515100   tyrosine protein kinase Fgr
Echinococcus multilocularis EmuJ_000132100   tyrosine protein kinase Fyn
Echinococcus multilocularis EmuJ_000580000   tyrosine protein kinase Srms
Echinococcus multilocularis EmuJ_000670400   proto oncogene tyrosine protein kinase LCK
Echinococcus multilocularis EmuJ_000584700   tyrosine protein kinase Blk
Echinococcus multilocularis EmuJ_000366500   tyrosine protein kinase lyn tyrosine protein kinase blk
Echinococcus multilocularis EmuJ_000598200   tyrosine protein kinase Src42A
Echinococcus multilocularis EmuJ_001116400   tyrosine protein kinase Src42A
Echinococcus multilocularis EmuJ_001155200   tyrosine protein kinase HCK
Echinococcus multilocularis EmuJ_000932000   tyrosine protein kinase Fyn
Homo sapiens ENSG00000197122   SRC proto-oncogene, non-receptor tyrosine kinase
Homo sapiens ENSG00000000938   FGR proto-oncogene, Src family tyrosine kinase
Homo sapiens ENSG00000010810   FYN proto-oncogene, Src family tyrosine kinase
Homo sapiens ENSG00000176105   YES proto-oncogene 1, Src family tyrosine kinase
Homo sapiens 2444   fyn-related Src family tyrosine kinase
Loa Loa (eye worm) LOAG_10645   TK protein kinase
Loa Loa (eye worm) LOAG_11106   TK protein kinase
Loa Loa (eye worm) LOAG_13767   SRC-1
Mus musculus ensembl-mmu:ENSMUSG00000019779   fyn-related kinase
Mus musculus ENSMUSG00000019843   Fyn proto-oncogene
Mus musculus ENSMUSG00000014932   Yamaguchi sarcoma viral (v-yes) oncogene homolog 1
Mus musculus ENSMUSG00000027646   Rous sarcoma oncogene
Mus musculus ENSMUSG00000028874   Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
Schistosoma japonicum Sjp_0068520   ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative
Schistosoma japonicum Sjp_0038770   Proto-oncogene tyrosine-protein kinase FGR, putative
Schistosoma japonicum Sjp_0100720   Proto-oncogene tyrosine-protein kinase Yrk, putative
Schistosoma japonicum Sjp_0103040   ko:K08892 fyn-related kinase, putative
Schistosoma japonicum Sjp_0065500   Proto-oncogene tyrosine-protein kinase FYN, putative
Schistosoma japonicum Sjp_0213890   Proto-oncogene tyrosine-protein kinase FYN, putative
Schistosoma mansoni Smp_006920   tyrosine kinase
Schistosoma mansoni Smp_136300   tyrosine kinase
Schmidtea mediterranea mk4.005658.00  
Schmidtea mediterranea mk4.000223.13  
Schmidtea mediterranea mk4.016246.01  
Schmidtea mediterranea mk4.026481.01  
Schmidtea mediterranea mk4.017378.01  
Schmidtea mediterranea mk4.007565.01  
Schmidtea mediterranea mk4.001280.02   Tyrosine-protein kinase Src64B
Schmidtea mediterranea mk4.002559.03  
Schmidtea mediterranea mk4.002809.01  
Schmidtea mediterranea mk4.031222.00  
Schmidtea mediterranea mk4.003671.00  
Schmidtea mediterranea mk4.020498.01  
Schmidtea mediterranea mk4.005009.01  

Essentiality

Sjp_0065500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y92H12A.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F49B2.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F49B2.5 Caenorhabditis elegans larval arrest wormbase
CELE_F49B2.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fyn-related Src family tyrosine kinase Compounds References
Rattus norvegicus Tyrosine-protein kinase FGR Compounds References
Homo sapiens YES proto-oncogene 1, Src family tyrosine kinase Compounds References
Mus musculus Rous sarcoma oncogene Compounds References
Rattus norvegicus Tyrosine-protein kinase SRC Compounds References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Compounds References
Homo sapiens FGR proto-oncogene, Src family tyrosine kinase Compounds References
Gallus gallus Tyrosine-protein kinase SRC Compounds References
Mus musculus Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog Compounds References
Homo sapiens FYN proto-oncogene, Src family tyrosine kinase Compounds References
Mus musculus Fyn proto-oncogene Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 33.5% 200 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 32.9% 152 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 26.2% 122 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0065500 (Schistosoma japonicum), Proto-oncogene tyrosine-protein kinase FYN, putative
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