Detailed view for Sjp_0015230
Basic information
Schistosoma japonicum, ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative
Source Database / ID: Wormbase Parasite
pI: 8.2279 |
Length (AA): 1147 |
MW (Da): 127161 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0005524 ATP binding
GO:0005515 protein binding
GO:0004713 protein tyrosine kinase activity
GO:0004672 protein kinase activity
GO:0006506 GPI anchor biosynthetic process
GO:0006468 protein amino acid phosphorylation
Metabolic Pathways
Structural information
Modbase 3D models:
There are 16 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 5 | 171 | 3gfp (A) | 305 | 477 | 26.00 | 0 | 1 | 0.475424 | -0.82 |
| 14 | 107 | 4i1s (A) | 700 | 806 | 22.00 | 0.0000022 | 0.99 | 0.373524 | -1.42 |
| 25 | 163 | 4db2 (A) | 370 | 511 | 39.00 | 0.000000000093 | 0.86 | 0.463991 | 0.32 |
| 68 | 143 | 3fho (A) | 390 | 466 | 47.00 | 0.18 | 0.51 | 0.114018 | 1.42 |
| 306 | 528 | 3lvq (E) | 449 | 11 | 22.00 | 0.000039 | 1 | 0.28509 | 0.6 |
| 345 | 564 | 5g4x (A) | 124 | 344 | 25.00 | 0 | 1 | 0.355472 | 0.27 |
| 365 | 499 | 1k1a (A) | 208 | 332 | 34.00 | 0.0001 | 1 | 0.510501 | -0.54 |
| 396 | 927 | 4o1p (A) | 27 | 494 | 20.00 | 0 | 1 | 0.330723 | 1.24 |
| 412 | 491 | 3deo (A) | 133 | 217 | 36.00 | 0.01 | 1 | 0.582508 | -1.34 |
| 435 | 556 | 4hrm (D) | 47 | 166 | 42.00 | 0 | 1 | 0.482957 | 0.04 |
| 439 | 568 | 1awc (B) | 10 | 136 | 29.00 | 0 | 1 | 0.469938 | -0.26 |
| 533 | 1054 | 4fl2 (A) | 137 | 633 | 35.00 | 0 | 1 | 0.577997 | 0.28 |
| 550 | 1062 | 1fmk (A) | 123 | 531 | 33.00 | 0 | 1 | 0.367144 | 0.81 |
| 566 | 671 | 2ekx (A) | 9 | 110 | 21.00 | 0.00000032 | 1 | 0.397996 | -0.65 |
| 569 | 670 | 1sha (A) | 4 | 102 | 23.00 | 0 | 1 | 0.450705 | -1.26 |
| 791 | 1062 | 4hzs (A) | 120 | 403 | 44.00 | 0 | 1 | 0.579047 | 0.47 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_131855)
| Species | Accession | Gene Product |
|---|---|---|
| Drosophila melanogaster | Dmel_CG18247 | SH2 ankyrin repeat kinase |
| Echinococcus granulosus | EgrG_000570700 | tyrosine protein kinase shark |
| Echinococcus multilocularis | EmuJ_000570700 | tyrosine protein kinase shark |
| Homo sapiens | ENSG00000165025 | spleen tyrosine kinase |
| Homo sapiens | ENSG00000115085 | zeta-chain (TCR) associated protein kinase 70kDa |
| Mus musculus | ENSMUSG00000026117 | zeta-chain (TCR) associated protein kinase |
| Mus musculus | ENSMUSG00000021457 | spleen tyrosine kinase |
| Schistosoma japonicum | Sjp_0026600 | ko:K05855 spleen tyrosine kinase, putative |
| Schistosoma japonicum | Sjp_0015230 | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative |
| Schistosoma mansoni | Smp_149460 | tyrosine kinase |
| Schistosoma mansoni | Smp_027400 | tyrosine kinase |
| Schmidtea mediterranea | mk4.001111.02 | Tyrosine-protein kinase shark |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | spleen tyrosine kinase | Compounds | References |
| Mus musculus | spleen tyrosine kinase | Compounds | References |
| Homo sapiens | zeta-chain (TCR) associated protein kinase 70kDa | Compounds | References |
| Mus musculus | zeta-chain (TCR) associated protein kinase | Compounds | References |
| Rattus norvegicus | Tyrosine-protein kinase SYK | Compounds | References |
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Sus scrofa | Casein kinase I isoform alpha | 125 aa | 27.0% | 126 aa | Compounds | References |
| Patiria pectinifera | Cdc2 | 300 aa | 26.4% | 258 aa | Compounds | References |
| Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 26.7% | 161 aa | Compounds | References |
| Rattus norvegicus | Jak1 protein | 210 aa | 34.3% | 201 aa | Compounds | References |
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References