Detailed view for Sjp_0214780

Basic information

TDR Targets ID: 973583
Schistosoma japonicum, High affinity choline transporter 1, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.3757 | Length (AA): 597 | MW (Da): 66478 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 13

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00474   Sodium:solute symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016020   membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

Cholinergic synapse (KEGG)
Choline metabolism in cancer (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131601)

Species Accession Gene Product
Brugia malayi Bm1_39525   GH02984p
Caenorhabditis elegans CELE_C48D1.3   Protein CHO-1
Drosophila melanogaster Dmel_CG7708   CG7708 gene product from transcript CG7708-RB
Echinococcus granulosus EgrG_001134800   high affinity choline transporter 1
Echinococcus multilocularis EmuJ_001134800   high affinity choline transporter 1
Homo sapiens ENSG00000115665   solute carrier family 5 (sodium/choline cotransporter), member 7
Loa Loa (eye worm) LOAG_00273   hypothetical protein
Mus musculus ENSMUSG00000023945   solute carrier family 5 (choline transporter), member 7
Schistosoma japonicum Sjp_0214780   High affinity choline transporter 1, putative
Schistosoma japonicum Sjp_0120610   IPR001734,Na+/solute symporter,domain-containing
Schistosoma mansoni Smp_150520   high-affinity choline transporter
Schmidtea mediterranea mk4.004711.03   High-affinity choline transporter 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus High affinity choline transporter 1 Compounds References
Mus musculus solute carrier family 5 (choline transporter), member 7 Compounds References
Homo sapiens solute carrier family 5 (sodium/choline cotransporter), member 7 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0214780 (Schistosoma japonicum), High affinity choline transporter 1, putative
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