Detailed view for Sjp_0000930

Basic information

TDR Targets ID: 973723
Schistosoma japonicum, ko:K01510 apyrase [EC3.6.1.5], putative
Source Database / ID:  Wormbase Parasite  

pI: 8.5957 | Length (AA): 515 | MW (Da): 58336 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01150   GDA1/CD39 (nucleoside phosphatase) family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
36 473 4a57 (A) 58 620 20.00 0 1 0.82994 0.14
42 478 3cj1 (A) 39 461 32.00 0 1 1.24489 -0.72
43 460 3zx0 (A) 49 458 40.00 0 1 1.21073 -0.46
43 460 3zx3 (A) 49 458 35.00 0 1 1.23603 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133039)

Species Accession Gene Product
Arabidopsis thaliana AT1G14240   probable apyrase 3
Arabidopsis thaliana AT1G14250   probable apyrase 5
Arabidopsis thaliana AT1G14230   probable apyrase 4
Echinococcus granulosus EgrG_000828300   ectonucleoside triphosphate diphosphohydrolase
Echinococcus multilocularis EmuJ_001128400   ectonucleoside triphosphate diphosphohydrolase
Echinococcus multilocularis EmuJ_000828350   ectonucleoside triphosphate diphosphohydrolase
Echinococcus multilocularis EmuJ_000828300   ectonucleoside triphosphate diphosphohydrolase
Homo sapiens ENSG00000138185   ectonucleoside triphosphate diphosphohydrolase 1
Mus musculus ENSMUSG00000048120   ectonucleoside triphosphate diphosphohydrolase 1
Oryza sativa 4345665   Os08g0436100
Plasmodium falciparum PF3D7_1431800   apyrase, putative
Schistosoma japonicum Sjp_0000930   ko:K01510 apyrase [EC3.6.1.5], putative
Schistosoma mansoni Smp_042020.1   ATP-diphosphohydrolase 1
Schmidtea mediterranea mk4.023807.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.001642.03   ATP-diphosphohydrolase 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ectonucleoside triphosphate diphosphohydrolase 1 Compounds References
Bos taurus Ectonucleoside triphosphate diphosphohydrolase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0000930 (Schistosoma japonicum), ko:K01510 apyrase [EC3.6.1.5], putative
Title for this comment
Comment