Detailed view for Sjp_0025910

Basic information

TDR Targets ID: 973740
Schistosoma japonicum, Transmembrane protease, serine 9, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.6086 | Length (AA): 299 | MW (Da): 33648 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00089   Trypsin

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 279 4kkd (B) 448 660 32.00 0 1 0.814369 1.41
42 108 2qy0 (B) 447 510 33.00 0 0.31 0.305532 1.46
42 88 2pka (A) 16 58 45.00 0.0001 0.81 0.372718 1.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_166843)

Species Accession Gene Product
Echinococcus granulosus EgrG_001046200   subfamily S1A unassigned peptidase S01 family
Echinococcus multilocularis EmuJ_001046200   subfamily S1A unassigned peptidase (S01 family)
Schistosoma japonicum Sjp_0206470   Enteropeptidase precursor, putative
Schistosoma japonicum Sjp_0025910   Transmembrane protease, serine 9, putative
Schistosoma mansoni Smp_112530   hypothetical protein
Schistosoma mansoni Smp_194090   subfamily S1A unassigned peptidase (S01 family)
Schistosoma mansoni Smp_174530   aminopeptidase PILS (M01 family)
Schmidtea mediterranea mk4.019014.00  
Schmidtea mediterranea mk4.000032.30  
Schmidtea mediterranea mk4.000567.07   Subfamily S1A unassigned peptidase
Schmidtea mediterranea mk4.015032.02  
Schmidtea mediterranea mk4.005543.00  
Schmidtea mediterranea mk4.001890.04  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Trypsin I 246 aa 23.6% 250 aa Compounds References
Oryctolagus cuniculus Thrombin 235 aa 25.0% 212 aa Compounds References
Rattus norvegicus Anionic trypsin-1 246 aa 23.2% 246 aa Compounds References
Canis lupus familiaris Tryptase 275 aa 24.8% 270 aa Compounds References
Sus scrofa Glandular kallikrein 246 aa 25.6% 250 aa Compounds References
Sus scrofa Trypsin 231 aa 21.1% 246 aa Compounds References
Bos taurus Trypsin II 247 aa 24.8% 246 aa Compounds References
Bos taurus Alpha-chymotrypsin 245 aa 22.5% 231 aa Compounds References
Rattus norvegicus Tryptase alpha/beta-1 273 aa 25.2% 242 aa Compounds References
Sus scrofa Elastase 1 266 aa 23.0% 222 aa Compounds References
Rattus norvegicus Trypsin II 246 aa 22.5% 249 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0025910 (Schistosoma japonicum), Transmembrane protease, serine 9, putative
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