Detailed view for Sjp_0096970

Basic information

TDR Targets ID: 973773
Schistosoma japonicum, ko:K04209 neuropeptide Y receptor, invertebrate, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.0595 | Length (AA): 519 | MW (Da): 59977 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004983   neuropeptide Y receptor activity  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

Neuroactive ligand-receptor interaction (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 363 4xt1 (A) 15 309 32.00 0 0.99 0.876451 0.27
47 118 4zj8 (A) 27 101 29.00 0.00002 0.02 0.161228 2.02
65 361 4ug2 (B) 8 304 20.00 0.0000000021 0.3 0.717754 -0.23
71 307 3kj6 (A) 41 312 35.00 0.00000000016 0.53 0.349747 1.42
75 361 2z73 (A) 46 331 27.00 0 0.24 0.750086 0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127863)

Species Accession Gene Product
Caenorhabditis elegans CELE_Y59H11AL.1   Protein NPR-22, isoform B
Caenorhabditis elegans CELE_F41E7.3   Protein NPR-6
Drosophila melanogaster Dmel_CG7395   short neuropeptide F receptor
Echinococcus granulosus EgrG_000966300   neuropeptide receptor
Echinococcus multilocularis EmuJ_000364400   G protein coupled receptor 139
Echinococcus multilocularis EmuJ_000966300   neuropeptide receptor
Homo sapiens ENSG00000185149   neuropeptide Y receptor Y2
Homo sapiens 2834   prolactin releasing hormone receptor
Homo sapiens ENSG00000137252   hypocretin (orexin) receptor 2
Mus musculus ENSMUSG00000045052   prolactin releasing hormone receptor
Mus musculus ENSMUSG00000032360   hypocretin (orexin) receptor 2
Mus musculus ENSMUSG00000028004   neuropeptide Y receptor Y2
Schistosoma japonicum Sjp_0096970   ko:K04209 neuropeptide Y receptor, invertebrate, putative
Schistosoma mansoni Smp_118040   neuropeptide receptor
Schmidtea mediterranea mk4.008463.05  
Schmidtea mediterranea mk4.021396.01  
Schmidtea mediterranea mk4.010969.00   Prolactin-releasing peptide receptor
Schmidtea mediterranea mk4.010792.03   Prolactin-releasing peptide receptor
Schmidtea mediterranea mk4.021285.00  
Schmidtea mediterranea mk4.013618.00  
Schmidtea mediterranea mk4.002618.00   Prolactin-releasing peptide receptor
Schmidtea mediterranea mk4.014127.00   Prolactin-releasing peptide receptor
Schmidtea mediterranea mk4.000375.06   Prolactin-releasing peptide receptor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Orexin receptor 2 Compounds References
Homo sapiens neuropeptide Y receptor Y2 Compounds References
Homo sapiens prolactin releasing hormone receptor Compounds References
Homo sapiens hypocretin (orexin) receptor 2 Compounds References
Mus musculus hypocretin (orexin) receptor 2 Compounds References
Rattus norvegicus Neuropeptide Y-Y2 receptor Compounds References
Rattus norvegicus Neuropeptide Y receptor type 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Canis lupus familiaris 5-hydroxytryptamine receptor 2A 470 aa 25.3% 411 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 20.7% 304 aa Compounds References
Macaca mulatta C-X-C chemokine receptor type 4 352 aa 24.8% 306 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 3 359 aa 25.4% 303 aa Compounds References
Rattus norvegicus G protein-coupled receptor 80 337 aa 25.1% 307 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 1 355 aa 25.5% 302 aa Compounds References
Rattus norvegicus Neurotensin receptor 2 416 aa 18.4% 347 aa Compounds References
Rattus norvegicus Pyrimidinergic receptor P2Y4 361 aa 21.9% 306 aa Compounds References
Rattus norvegicus Melanin-concentrating hormone receptor 1 360 aa 26.3% 315 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 23.8% 307 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 27.2% 323 aa Compounds References
Bos taurus Uncharacterized protein 372 aa 25.4% 315 aa Compounds References
Macaca mulatta G-protein coupled receptor 81 337 aa 22.6% 319 aa Compounds References
Microtus ochrogaster Vasopressin V1a receptor 420 aa 21.2% 344 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 26.2% 301 aa Compounds References
Oryctolagus cuniculus Motilin receptor 400 aa 24.6% 341 aa Compounds References
Macaca mulatta Melanin-concentrating hormone receptor 1 388 aa 26.0% 315 aa Compounds References
Rattus norvegicus Beta-3 adrenergic receptor 400 aa 22.2% 324 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 21.7% 332 aa Compounds References
Cavia porcellus Cysteinyl leukotriene receptor 2 317 aa 27.0% 315 aa Compounds References
Cavia porcellus Kappa opioid receptor 380 aa 26.2% 313 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 3 355 aa 24.7% 300 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 2 373 aa 25.1% 347 aa Compounds References
Rattus norvegicus Purinergic receptor P2Y1 373 aa 22.6% 328 aa Compounds References
Rattus norvegicus Adenosine A1 receptor 326 aa 21.6% 315 aa Compounds References
Rattus norvegicus Vasopressin V1a receptor 424 aa 21.6% 348 aa Compounds References
Sus scrofa Delta opioid receptor 228 aa 27.4% 241 aa Compounds References
Cavia porcellus Cholecystokinin A receptor 430 aa 27.5% 356 aa Compounds References
Rattus norvegicus Sphingosine 1-phosphate receptor 2 352 aa 23.3% 301 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 25.6% 297 aa Compounds References
Rattus norvegicus Platelet activating factor receptor 341 aa 23.0% 330 aa Compounds References
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor 359 aa 22.8% 329 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 26.8% 269 aa Compounds References
Cavia porcellus Platelet activating factor receptor 342 aa 23.8% 340 aa Compounds References
Rattus norvegicus Serotonin 2a (5-HT2a) receptor 471 aa 25.4% 405 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 26.5% 98 aa Compounds References
Rattus norvegicus G protein-coupled receptor GPR35 306 aa 23.3% 270 aa Compounds References
Bos taurus Angiotensin II type 1a (AT-1a) receptor 359 aa 24.1% 324 aa Compounds References
Macaca mulatta C-C chemokine receptor type 3 355 aa 25.1% 299 aa Compounds References
Macaca fascicularis G-protein coupled receptor 119 335 aa 21.0% 328 aa Compounds References
Rattus norvegicus Prostanoid EP3 receptor 365 aa 23.9% 293 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 26.1% 307 aa Compounds References
Rattus norvegicus Somatostatin receptor 363 aa 27.4% 292 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 27.9% 301 aa Compounds References
Rattus norvegicus Adenosine A2a receptor 410 aa 23.6% 352 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 27.2% 323 aa Compounds References
Rattus norvegicus Melanocortin receptor 3 323 aa 19.9% 291 aa Compounds References
Gallus gallus Adenosine A1 receptor 324 aa 21.6% 352 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 22.2% 315 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 23.1% 316 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 24.3% 350 aa Compounds References
Sus scrofa A1 adenosine receptor 326 aa 21.8% 317 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 21.7% 332 aa Compounds References
Sus scrofa Type-1 angiotensin II receptor 359 aa 23.8% 311 aa Compounds References
Rattus norvegicus Histamine H4 receptor 391 aa 20.5% 385 aa Compounds References
Canis lupus familiaris C-X-C chemokine receptor type 3 365 aa 22.0% 296 aa Compounds References
Rattus norvegicus Adrenergic receptor beta 400 aa 22.2% 324 aa Compounds References
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 359 aa 24.1% 307 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 4 375 aa 32.7% 312 aa Compounds References
Cavia porcellus mu/kappa opioid receptor 380 aa 26.2% 313 aa Compounds References
Oryctolagus cuniculus C-X-C chemokine receptor type 2 358 aa 24.0% 317 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 5 352 aa 23.3% 331 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor 1/lysophosphatidic acid receptor 3 354 aa 24.9% 334 aa Compounds References
Canis familiaris Chemokine (C-C motif) receptor 1 354 aa 25.5% 302 aa Compounds References
Cavia porcellus Serotonin 7 (5-HT7) receptor 446 aa 23.0% 374 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 21.8% 348 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 24.5% 294 aa Compounds References
Cavia porcellus Cysteinyl leukotriene receptor 1 340 aa 25.1% 307 aa Compounds References
Rattus norvegicus Succinate receptor 1 317 aa 22.2% 297 aa Compounds References
Rattus norvegicus Cannabinoid CB2 receptor 360 aa 20.6% 311 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 24.1% 295 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 21.8% 348 aa Compounds References
Meriones unguiculatus Substance-P receptor 407 aa 25.8% 356 aa Compounds References
Rattus norvegicus C5a anaphylatoxin chemotactic receptor 352 aa 26.4% 314 aa Compounds References
Rattus norvegicus Type-1A angiotensin II receptor 359 aa 23.5% 311 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor Edg-7 354 aa 24.9% 334 aa Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor 406 aa 25.1% 407 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 22.0% 327 aa Compounds References
Bos taurus Adenosine A1 receptor 326 aa 22.3% 318 aa Compounds References
Cavia porcellus Neurokinin 1 receptor 407 aa 26.1% 341 aa Compounds References
Sus scrofa Serotonin 2a (5-HT2a) receptor 470 aa 25.3% 411 aa Compounds References
Rattus norvegicus Angiotensin II receptor 359 aa 23.5% 311 aa Compounds References
Rattus norvegicus Bombesin receptor subtype-3 399 aa 27.2% 327 aa Compounds References
Rattus norvegicus Adenosine A3 receptor 320 aa 24.3% 304 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 23.2% 263 aa Compounds References
Cavia porcellus Adenosine A1 receptor 326 aa 21.1% 317 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 1 382 aa 31.8% 308 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 23.6% 364 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 23.8% 307 aa Compounds References
Rattus norvegicus Purinergic receptor P2Y2 374 aa 22.3% 327 aa Compounds References
Cavia porcellus Type-1 angiotensin II receptor 359 aa 23.8% 311 aa Compounds References
Rattus norvegicus Melanocortin receptor 4 332 aa 24.4% 295 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 22.2% 347 aa Compounds References
Macaca mulatta Sphingosine 1-phosphate receptor 1 382 aa 24.9% 313 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 24.3% 309 aa Compounds References
Rattus norvegicus Pyrimidinergic receptor P2Y6 328 aa 22.0% 314 aa Compounds References
Rattus norvegicus Galanin receptor 1 346 aa 26.0% 315 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 20.8% 331 aa Compounds References
Rattus norvegicus Delta opioid receptor 372 aa 28.6% 315 aa Compounds References
Rattus norvegicus Oxytocin receptor 388 aa 19.3% 327 aa Compounds References
Rattus norvegicus Adenosine A2 receptor 410 aa 23.6% 352 aa Compounds References
Rattus norvegicus Melatonin receptor 1B 364 aa 27.3% 293 aa Compounds References
Oryctolagus cuniculus Bradykinin B2 receptor 367 aa 24.5% 294 aa Compounds References
Canis lupus familiaris Uncharacterized protein 335 aa 22.6% 279 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 26.8% 313 aa Compounds References
Rattus norvegicus C-X-C chemokine receptor type 4 349 aa 23.5% 310 aa Compounds References
Rattus norvegicus Melanocortin receptor 5 325 aa 21.7% 300 aa Compounds References
Human cytomegalovirus G protein-coupled receptor 354 aa 26.8% 310 aa Compounds References
Sus scrofa Angiotensin type II receptor 137 aa 28.7% 136 aa Compounds References
Rattus norvegicus Histamine H2 receptor 358 aa 23.5% 327 aa Compounds References
Danio rerio Mu opioid receptor-like OR2 384 aa 27.1% 329 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 28.8% 288 aa Compounds References
Rattus norvegicus Protein Gpr39 298 aa 24.2% 264 aa Compounds References
Rattus norvegicus Somatostatin receptor 2 369 aa 28.7% 300 aa Compounds References
Rattus norvegicus Opioid receptor 372 aa 28.6% 315 aa Compounds References
Bos taurus Beta-2 adrenergic receptor 418 aa 26.0% 407 aa Compounds References
Rattus norvegicus Protein Gpr81 351 aa 22.9% 293 aa Compounds References
Pan troglodytes Uncharacterized protein 338 aa 22.3% 323 aa Compounds References
Oryctolagus cuniculus Bradykinin B1 receptor 352 aa 24.1% 323 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 26.1% 299 aa Compounds References
Rattus norvegicus Type-1B angiotensin II receptor 359 aa 24.1% 307 aa Compounds References
Rattus norvegicus Neurotensin receptor 1 424 aa 22.7% 344 aa Compounds References
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 chemokine receptor 354 aa 27.0% 330 aa Compounds References
Rattus norvegicus Gastrin releasing peptide receptor 384 aa 27.8% 327 aa Compounds References
Mesocricetus auratus Beta-2 adrenergic receptor 418 aa 23.6% 386 aa Compounds References
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor 363 aa 23.5% 310 aa Compounds References
Sus scrofa Serotonin 4 (5-HT4) receptor 402 aa 26.5% 344 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 23.6% 364 aa Compounds References
Cavia porcellus Adenosine A2a receptor 409 aa 22.3% 417 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 19.5% 302 aa Compounds References
Gallus gallus Oxytocin-like receptor 391 aa 21.9% 324 aa Compounds References
Macaca mulatta C-C chemokine receptor type 5 352 aa 23.3% 331 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 28.8% 66 aa Compounds References
Meleagris gallopavo P2Y purinoceptor 1 362 aa 22.3% 300 aa Compounds References
Canis lupus familiaris Bradykinin B1 receptor 350 aa 23.5% 311 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 28.6% 304 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 25.3% 316 aa Compounds References
Canis lupus familiaris Adenosine receptor A3 314 aa 23.3% 305 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 28.7% 265 aa Compounds References
Oryctolagus cuniculus Chemokine receptor 351 aa 24.0% 308 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 28.3% 329 aa Compounds References
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 23.2% 375 aa Compounds References
Rattus norvegicus Neurokinin 1 receptor 407 aa 25.3% 352 aa Compounds References
Rattus norvegicus Beta-2 adrenergic receptor 418 aa 23.4% 351 aa Compounds References
Cricetulus griseus Prokineticin receptor 2 391 aa 28.9% 329 aa Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor 388 aa 27.3% 326 aa Compounds References
Rattus norvegicus Somatostatin receptor 5 363 aa 27.4% 292 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 25.2% 341 aa Compounds References
Rattus norvegicus Neuromedin B receptor 390 aa 25.8% 387 aa Compounds References
Bos taurus Rhodopsin 348 aa 28.4% 317 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor Edg-2 364 aa 23.9% 347 aa Compounds References
Oryctolagus cuniculus Adenosine A1 receptor 328 aa 21.7% 323 aa Compounds References
Rattus norvegicus Purinergic receptor P2Y12 343 aa 23.5% 328 aa Compounds References
Cavia porcellus Histamine H2 receptor 359 aa 24.3% 305 aa Compounds References
Rattus norvegicus Hydroxycarboxylic acid receptor 2 360 aa 24.0% 296 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 7b 358 aa 21.9% 315 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0096970 (Schistosoma japonicum), ko:K04209 neuropeptide Y receptor, invertebrate, putative
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