Detailed view for Sjp_0002740

Basic information

TDR Targets ID: 973875
Schistosoma japonicum, ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.3298 | Length (AA): 469 | MW (Da): 53723 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 3

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02931   Neurotransmitter-gated ion-channel ligand binding domain
PF02932   Neurotransmitter-gated ion-channel transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0034220   transmembrane ion transport  
GO:0022848   acetylcholine-gated cation channel activity  
GO:0045211   postsynaptic membrane  
GO:0016021   integral to membrane  
GO:0005230   extracellular ligand-gated ion channel activity  
GO:0005216   ion channel activity  
GO:0004888   transmembrane receptor activity  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 306 5kxi (A) 61 366 41.00 0.000022 0.99 1.01815 0.98
193 224 1dxz (A) 236 267 47.00 0.0016 0.41 0.502976 0.67
270 369 1sxj (D) 249 353 28.00 0.76 0.07 0.447275 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130932)

Species Accession Gene Product
Brugia malayi Bm1_48815   Cation transporter family protein
Caenorhabditis elegans CELE_F25G6.3   Protein ACR-16, isoform B
Drosophila melanogaster Dmel_CG4128   nicotinic Acetylcholine Receptor alpha6
Drosophila melanogaster Dmel_CG32538   nicotinic Acetylcholine Receptor alpha7
Drosophila melanogaster Dmel_CG32975   nicotinic Acetylcholine Receptor alpha5
Homo sapiens ENSG00000166664   CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Homo sapiens 101929970   CHRNA7-FAM7A fusion protein-like
Homo sapiens 1139   cholinergic receptor, nicotinic, alpha 7 (neuronal)
Loa Loa (eye worm) LOAG_15221   hypothetical protein
Loa Loa (eye worm) LOAG_04698   hypothetical protein
Loa Loa (eye worm) LOAG_11091   hypothetical protein
Mus musculus ENSMUSG00000030525   cholinergic receptor, nicotinic, alpha polypeptide 7
Onchocerca volvulus OVOC929c  
Onchocerca volvulus OVOC929b  
Onchocerca volvulus OVOC929a  
Schistosoma japonicum Sjp_0002740   ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative
Schistosoma japonicum Sjp_0082390   Neuronal acetylcholine receptor subunit alpha-7 precursor, putative
Schistosoma japonicum Sjp_0002760   IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing
Schistosoma japonicum Sjp_0002750   Neuronal acetylcholine receptor subunit alpha-7 precursor, putative
Schistosoma japonicum Sjp_0055750   Neuronal acetylcholine receptor subunit alpha-7 precursor, putative
Schistosoma mansoni Smp_031680   nAChR subunit (ShAR1-alpha-like)
Schistosoma mansoni Smp_139330   nAChR subunit (ShAR1-beta-like)
Schmidtea mediterranea mk4.015311.00   Nicotinic acetylcholine receptor beta 3
Schmidtea mediterranea mk4.000109.04  
Schmidtea mediterranea mk4.005328.04  
Schmidtea mediterranea mk4.019683.00  
Schmidtea mediterranea mk4.002409.04   NAChR subunit
Schmidtea mediterranea mk4.025583.00   Nicotinic acetylcholine receptor beta 3
Schmidtea mediterranea mk4.001717.01  
Schmidtea mediterranea mk4.029788.01  
Schmidtea mediterranea mk4.004482.06  
Schmidtea mediterranea mk4.000109.05  
Schmidtea mediterranea mk4.001224.00   Putative nicotinic acetylcholine receptor alpha

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha5 Compounds References
Macaca mulatta Neuronal acetylcholine receptor subunit alpha-7 Compounds References
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha7 Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Compounds References
Mus musculus cholinergic receptor, nicotinic, alpha polypeptide 7 Compounds References
Lymnaea stagnalis Acetylcholine-binding protein Compounds References
Homo sapiens cholinergic receptor, nicotinic, alpha 7 (neuronal) Compounds References
Aplysia californica Soluble acetylcholine receptor Compounds References
Musca domestica Nicotinic acetylcholine receptor alpha 5 subunit Compounds References
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0002740 (Schistosoma japonicum), ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative
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