Detailed view for Sjp_0026600

Basic information

TDR Targets ID: 973932
Schistosoma japonicum, ko:K05855 spleen tyrosine kinase, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.7838 | Length (AA): 1011 | MW (Da): 111296 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00017   SH2 domain
PF07714   Protein tyrosine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 381 4fl2 (A) 74 464 24.00 0 1 0.357087 1.25
14 194 1a81 (E) 79 258 35.00 0.0000000000066 1 0.237008 1.23
61 195 4m4z (A) 53 191 28.00 0 0.99 0.402463 0.01
103 196 1kc2 (A) 148 248 33.00 0.006 1 0.594869 -1.31
103 198 2vif (A) 382 480 43.00 0.00011 0.9 0.42185 0.14
103 195 2ekx (A) 11 109 27.00 0 1 0.364579 -0.53
105 211 2dm0 (A) 18 123 36.00 0.000011 1 0.401741 -0.05
499 537 2pne (A) 10 57 51.00 0.19 0.07 0.286414 0.2
558 879 5mo4 (A) 177 517 30.00 0 1 0.544312 0.23
637 877 4ueu (A) 0 262 41.00 0 1 0.613414 -0.04
895 934 4kru (A) 0 34 40.00 0.22 0.05 0.516404 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131855)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG18247   SH2 ankyrin repeat kinase
Echinococcus granulosus EgrG_000570700   tyrosine protein kinase shark
Echinococcus multilocularis EmuJ_000570700   tyrosine protein kinase shark
Homo sapiens ENSG00000165025   spleen tyrosine kinase
Homo sapiens ENSG00000115085   zeta-chain (TCR) associated protein kinase 70kDa
Mus musculus ENSMUSG00000026117   zeta-chain (TCR) associated protein kinase
Mus musculus ENSMUSG00000021457   spleen tyrosine kinase
Schistosoma japonicum Sjp_0026600   ko:K05855 spleen tyrosine kinase, putative
Schistosoma japonicum Sjp_0015230   ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative
Schistosoma mansoni Smp_149460   tyrosine kinase
Schistosoma mansoni Smp_027400   tyrosine kinase
Schmidtea mediterranea mk4.001111.02   Tyrosine-protein kinase shark

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus spleen tyrosine kinase Compounds References
Homo sapiens spleen tyrosine kinase Compounds References
Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa Compounds References
Rattus norvegicus Tyrosine-protein kinase SYK Compounds References
Mus musculus zeta-chain (TCR) associated protein kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 30.1% 193 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 26.3% 156 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0026600 (Schistosoma japonicum), ko:K05855 spleen tyrosine kinase, putative
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