Detailed view for Sjp_0025060

Basic information

TDR Targets ID: 974036
Schistosoma japonicum, ko:K06059 a disintegrin and metalloproteinase domain 17, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.2205 | Length (AA): 752 | MW (Da): 85046 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01562   Reprolysin family propeptide
PF13688   Metallo-peptidase family M12

Gene Ontology

Mouse over links to read term descriptions.
GO:0008237   metallopeptidase activity  
GO:0004222   metalloendopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
196 550 2ero (A) 199 504 32.00 0 1 0.617203 0.55
457 529 3uci (A) 0 65 36.00 0.0006 0.94 0.451704 -0.31
459 530 1j2l (A) 1 66 41.00 0 1 0.448372 -0.3
525 584 2cqw (A) 5 63 44.00 0.5 0.69 0.132393 1.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132656)

Species Accession Gene Product
Caenorhabditis elegans CELE_ZK154.7   Protein ADM-4
Drosophila melanogaster Dmel_CG7908   CG7908 gene product from transcript CG7908-RB
Echinococcus granulosus EgrG_000892700   Blood coagulation inhibitor Disintegrin
Echinococcus granulosus EgrG_000892800   adam 17 protease
Echinococcus multilocularis EmuJ_000892800   adam 17 protease
Echinococcus multilocularis EmuJ_000892700   Blood coagulation inhibitor, Disintegrin
Homo sapiens ENSG00000151694   ADAM metallopeptidase domain 17
Loa Loa (eye worm) LOAG_03310   hypothetical protein
Mus musculus ENSMUSG00000052593   a disintegrin and metallopeptidase domain 17
Schistosoma japonicum Sjp_0025060   ko:K06059 a disintegrin and metalloproteinase domain 17, putative
Schistosoma mansoni Smp_175340.1   ADAM17 peptidase (M12 family)
Schmidtea mediterranea mk4.002318.03  
Schmidtea mediterranea mk4.004771.02   ADAM 17-like protease
Schmidtea mediterranea mk4.004771.01   ADAM 17-like protease
Schmidtea mediterranea mk4.004771.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus ADAM17 Compounds References
Mus musculus a disintegrin and metallopeptidase domain 17 Compounds References
Homo sapiens ADAM metallopeptidase domain 17 Compounds References
Sus scrofa ADAM17 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0025060 (Schistosoma japonicum), ko:K06059 a disintegrin and metalloproteinase domain 17, putative
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