Detailed view for Sjp_0051570

Basic information

TDR Targets ID: 974125
Schistosoma japonicum, FAD-linked sulfhydryl oxidase ALR, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.5423 | Length (AA): 169 | MW (Da): 19689 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04777   Erv1 / Alr family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016972   thiol oxidase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 156 4e0i (A) 17 187 42.00 0 1 1.38054 -0.55
51 160 1oqc (A) 14 123 59.00 0 1 1.49546 -1.62
53 152 2hj3 (A) 8 107 46.00 0 1 1.33094 -1.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127535)

Species Accession Gene Product
Arabidopsis thaliana AT1G49880   FAD-linked sulfhydryl oxidase ERV1
Babesia bovis BBOV_II007550   human hepatopoietin-like protein, putative
Brugia malayi Bm1_33230   Augmenter of liver regeneration
Candida albicans CaO19.13905   similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase
Candida albicans CaO19.6552   similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase
Candida albicans CaO19_6552   hypothetical protein
Caenorhabditis elegans CELE_F56C11.3   Protein F56C11.3
Dictyostelium discoideum DDB_G0272230   hypothetical protein
Drosophila melanogaster Dmel_CG12534   Augmenter of liver regeneration
Echinococcus granulosus EgrG_001126400   FAD linked sulfhydryl oxidase ALR
Echinococcus multilocularis EmuJ_001126400   FAD linked sulfhydryl oxidase ALR
Homo sapiens ENSG00000127554   growth factor, augmenter of liver regeneration
Leishmania braziliensis LbrM.15.1000   hypothetical protein, conserved
Leishmania donovani LdBPK_151020.1   ERV/ALR sulfhydryl oxidase domain-containing protein
Leishmania infantum LinJ.15.1020   hypothetical protein, conserved
Leishmania major LmjF.15.0960   hypothetical protein, conserved
Leishmania mexicana LmxM.15.0960   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05818   hepatopoietin HPO2
Mus musculus ENSMUSG00000040888   growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
Neospora caninum NCLIV_041090   hypothetical protein
Oryza sativa 9270137   Os03g0206300
Plasmodium berghei PBANKA_0203400   FAD-linked sulfhydryl oxidase ERV1, putative
Plasmodium falciparum PF3D7_0110200   FAD-linked sulfhydryl oxidase ERV1, putative
Plasmodium knowlesi PKNH_0203600   FAD-linked sulfhydryl oxidase ERV1, putative
Plasmodium vivax PVX_081280   FAD-linked sulfhydryl oxidase ERV1, putative
Plasmodium yoelii PY00421   hypothetical protein
Saccharomyces cerevisiae YGR029W   Erv1p
Saccharomyces cerevisiae YPR037C   Erv2p
Schistosoma japonicum Sjp_0051570   FAD-linked sulfhydryl oxidase ALR, putative
Schmidtea mediterranea mk4.000083.18   FAD-linked sulfhydryl oxidase ALR
Trypanosoma brucei gambiense Tbg972.9.3150   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.6060   ERV/ALR sulfhydryl oxidase domain-containing protein
Trypanosoma congolense TcIL3000_9_2060   ERV/ALR sulfhydryl oxidase domain-containing protein
Trypanosoma congolense TcIL3000_9_2050   ERV/ALR sulfhydryl oxidase domain-containing protein
Trypanosoma cruzi TcCLB.505843.49   Present in the outer mitochondrial membrane proteome 4
Trypanosoma cruzi TcCLB.430605.40   Present in the outer mitochondrial membrane proteome 4
Trypanosoma cruzi TcCLB.509353.20   ERV/ALR sulfhydryl oxidase domain-containing protein
Toxoplasma gondii TGME49_210787   Erv1 / Alr family protein
Toxoplasma gondii TGME49_288620   Erv1 / Alr family protein
Theileria parva TP02_0206   hypothetical protein, conserved

Essentiality

Sjp_0051570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.4440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.4440 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.4440 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.4440 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YGR029W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0203400 Plasmodium berghei Essential plasmo
TGME49_288620 Toxoplasma gondii Essentiality uncertain sidik
TGME49_210787 Toxoplasma gondii Essentiality uncertain sidik
TGME49_288620 Toxoplasma gondii Probably essential sidik
TGME49_210787 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens growth factor, augmenter of liver regeneration Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0051570 (Schistosoma japonicum), FAD-linked sulfhydryl oxidase ALR, putative
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