Detailed view for Sjp_0035090

Basic information

TDR Targets ID: 974225
Schistosoma japonicum, Scm-like with four MBT domains protein 1, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.9585 | Length (AA): 1248 | MW (Da): 140739 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02820   mbt repeat
PF12140   SLED domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0042393   histone binding  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0003714   transcription corepressor activity  
GO:0005634   nucleus  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 414 3f70 (B) 177 514 31.00 0.00000018 0.64 0.195391 1.51
5 259 2biv (A) 32 240 24.00 0 0.9 0.226691 0.39
6 399 3ut1 (A) 232 543 26.00 0 0.97 0.281158 0.63
307 347 2p0k (A) 162 202 49.00 0.67 0.75 0.370679 1.6
1121 1197 2kp6 (A) 2 74 34.00 0.34 0.18 0.343548 -0.21
1159 1227 4pzo (A) 914 983 28.00 0.5 1 0.482133 -0.84
1160 1225 5j8y (C) 1136 1201 21.00 0.0005 0.67 0.443727 -1.4
1172 1226 5f3x (B) 357 410 20.00 0.023 0.91 0.420906 -1.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133554)

Species Accession Gene Product
Echinococcus granulosus EgrG_000978600   SAM and MBT domain containing protein
Echinococcus multilocularis EmuJ_000978600   SAM and MBT domain containing protein
Homo sapiens ENSG00000163935   Scm-like with four mbt domains 1
Homo sapiens ENSG00000198879   Scm-like with four mbt domains 2
Mus musculus ENSMUSG00000006527   Scm-like with four mbt domains 1
Mus musculus ENSMUSG00000061186   Scm-like with four mbt domains 2
Schistosoma japonicum Sjp_0035090   Scm-like with four MBT domains protein 1, putative
Schistosoma mansoni Smp_074050   scm-relatedprotein containing 4 mbt domains (sfmbt)
Schmidtea mediterranea mk4.005320.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens Scm-like with four mbt domains 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0035090 (Schistosoma japonicum), Scm-like with four MBT domains protein 1, putative
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