Detailed view for Sjp_0041610

Basic information

TDR Targets ID: 974526
Schistosoma japonicum, Poly [ADP-ribose] polymerase 1, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.0608 | Length (AA): 279 | MW (Da): 31735 | Paralog Number: 5

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05406   WGR domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
138 267 2cr9 (A) 11 138 48.00 0 1 0.981326 0.31
169 262 2eoc (A) 64 155 33.00 0.0000005 0.41 0.66093 -0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128423)

Species Accession Gene Product
Arabidopsis thaliana AT4G02390   poly(ADP-ribose) polymerase
Arabidopsis thaliana AT2G31320   poly [ADP-ribose] polymerase 2
Brugia malayi Bm1_50905   WGR domain containing protein
Brugia malayi Bm1_07920   WGR domain containing protein
Caenorhabditis elegans CELE_Y71F9AL.18   Protein PME-1
Dictyostelium discoideum DDB_G0292820   NAD+ ADP-ribosyltransferase
Dictyostelium discoideum DDB_G0278741   NAD+ ADP-ribosyltransferase
Drosophila melanogaster Dmel_CG40411   Poly-(ADP-ribose) polymerase
Echinococcus granulosus EgrG_002060500   poly (ADP ribose) polymerase
Echinococcus granulosus EgrG_002063300   WGR domain containing protein
Echinococcus granulosus EgrG_000618800   poly adp ribose polymerase 2
Echinococcus granulosus EgrG_000566400   poly (ADP ribose) polymerase
Echinococcus granulosus EgrG_002059300   poly (ADP ribose) polymerase
Echinococcus granulosus EgrG_000374500   poly ADP ribose polymerase 1
Entamoeba histolytica EHI_136960   poly(ADP-ribose) polymerase, putative
Entamoeba histolytica EHI_038830   hypothetical protein
Echinococcus multilocularis EmuJ_000566800   poly (ADP ribose) polymerase
Echinococcus multilocularis EmuJ_000374500   poly (ADP ribose) polymerase 1
Echinococcus multilocularis EmuJ_000618800   poly (adp ribose) polymerase 2
Homo sapiens ENSG00000143799   poly (ADP-ribose) polymerase 1
Homo sapiens ENSG00000129484   poly (ADP-ribose) polymerase 2
Loa Loa (eye worm) LOAG_07925   hypothetical protein
Loa Loa (eye worm) LOAG_03373   hypothetical protein
Loa Loa (eye worm) LOAG_13695   poly(ADP-ribose) polymerase
Mus musculus ENSMUSG00000026496   poly (ADP-ribose) polymerase family, member 1
Mus musculus ENSMUSG00000036023   poly (ADP-ribose) polymerase family, member 2
Neospora caninum NCLIV_035940   hypothetical protein
Oryza sativa 4326478   Os01g0351100
Oryza sativa 4343013   Os07g0413700
Oryza sativa 4326479   Os01g0351200
Schistosoma japonicum Sjp_0303330   ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative
Schistosoma japonicum Sjp_0069220   Poly [ADP-ribose] polymerase 2, putative
Schistosoma japonicum Sjp_0041610   Poly [ADP-ribose] polymerase 1, putative
Schistosoma japonicum Sjp_0110660   Poly [ADP-ribose] polymerase 2-A, putative
Schistosoma japonicum Sjp_0311610   Poly [ADP-ribose] polymerase 2, putative
Schistosoma japonicum Sjp_0086100   Poly [ADP-ribose] polymerase 1, putative
Schistosoma mansoni Smp_145810.2   poly [ADP-ribose] polymerase
Schistosoma mansoni Smp_145810.1   poly [ADP-ribose] polymerase
Schistosoma mansoni Smp_129260   poly [ADP-ribose] polymerase
Schmidtea mediterranea mk4.001452.11  
Schmidtea mediterranea mk4.005407.00   Poly
Schmidtea mediterranea mk4.005407.01   Poly
Schmidtea mediterranea mk4.013382.00   Poly
Schmidtea mediterranea mk4.003480.01   Poly(ADP-ribose) polymerase pme-2
Trypanosoma brucei gambiense Tbg972.5.4270   poly(ADP-ribose) polymerase, putative
Trypanosoma brucei Tb927.5.3050   poly(adp-ribose) polymerase
Trypanosoma congolense TcIL3000_5_3380   poly(ADP-ribose) polymerase, putative
Trypanosoma cruzi TcCLB.510173.90   poly(ADP-ribose) polymerase, putative
Trypanosoma cruzi TcCLB.509721.60   poly(ADP-ribose) polymerase, putative
Toxoplasma gondii TGME49_270840   poly(ADP-ribose) polymerase catalytic domain-containing protein

Essentiality

Sjp_0041610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.3050 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.3050 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.3050 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.3050 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_270840 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus poly (ADP-ribose) polymerase family, member 1 Compounds References
Homo sapiens poly (ADP-ribose) polymerase 2 Compounds References
Homo sapiens poly (ADP-ribose) polymerase 1 Compounds References
Bos taurus Poly [ADP-ribose] polymerase 1 Compounds References
Rattus norvegicus Poly [ADP-ribose] polymerase 1 Compounds References
Mus musculus poly (ADP-ribose) polymerase family, member 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0041610 (Schistosoma japonicum), Poly [ADP-ribose] polymerase 1, putative
Title for this comment
Comment