Detailed view for Sjp_0100150

Basic information

TDR Targets ID: 974557
Schistosoma japonicum, ko:K00924 G-protein-coupled Receptor Kinase [EC:2.7.1.-], putative
Source Database / ID:  Wormbase Parasite  

pI: 7.5013 | Length (AA): 395 | MW (Da): 45375 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00615   Regulator of G protein signaling domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004703   G-protein coupled receptor kinase activity  
GO:0004672   protein kinase activity  
GO:0007165   signal transduction  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 86 1jnu (A) 938 1025 13.00 0.000078 0.06 0.234374 0.83
29 394 3uzs (A) 29 389 75.00 0 1 1.75323 -0.1
31 394 5uuu (A) 31 389 83.00 0 1 1.44516 0.83
54 178 1dk8 (A) 125 247 22.00 0.027 0.94 0.724359 -1.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131467)

Species Accession Gene Product
Caenorhabditis elegans CELE_W02B3.2   Protein GRK-2
Drosophila melanogaster Dmel_CG40129   G protein-coupled receptor kinase 1
Echinococcus granulosus EgrG_000225500   beta-adrenergic receptor kinase
Echinococcus granulosus EgrG_001083700   G protein coupled receptor kinase 1
Echinococcus multilocularis EmuJ_001083700   G protein coupled receptor kinase 1
Echinococcus multilocularis EmuJ_000225500   beta adrenergic receptor kinase
Homo sapiens ENSG00000100077   adrenergic, beta, receptor kinase 2
Homo sapiens ENSG00000173020   adrenergic, beta, receptor kinase 1
Loa Loa (eye worm) LOAG_06661   AGC/GRK/BARK protein kinase
Mus musculus ENSMUSG00000042249   adrenergic receptor kinase, beta 2
Mus musculus ENSMUSG00000024858   adrenergic receptor kinase, beta 1
Schistosoma japonicum Sjp_0219020   G protein-coupled receptor kinase 1, putative
Schistosoma japonicum Sjp_0109030   hypothetical protein
Schistosoma japonicum Sjp_0100150   ko:K00924 G-protein-coupled Receptor Kinase [EC:2.7.1.-], putative
Schistosoma mansoni Smp_159010.1   serine/threonine protein kinase
Schistosoma mansoni Smp_159010.2   serine/threonine protein kinase
Schmidtea mediterranea mk4.002476.03  
Schmidtea mediterranea mk4.001994.04  
Schmidtea mediterranea mk4.007097.00   G protein-coupled receptor kinase 2
Schmidtea mediterranea mk4.007097.02   G protein-coupled receptor kinase 1
Schmidtea mediterranea mk4.001994.03   G protein-coupled receptor kinase 1
Schmidtea mediterranea mk4.011144.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adrenergic, beta, receptor kinase 1 Compounds References
Homo sapiens adrenergic, beta, receptor kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Casein kinase I isoform alpha 125 aa 25.7% 109 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0100150 (Schistosoma japonicum), ko:K00924 G-protein-coupled Receptor Kinase [EC:2.7.1.-], putative
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