Detailed view for Sjp_0307290

Basic information

TDR Targets ID: 974743
Schistosoma japonicum, Sodium/potassium-transporting ATPase subunit alpha, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.7111 | Length (AA): 135 | MW (Da): 15717 | Paralog Number: 5

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00690   Cation transporter/ATPase, N-terminus

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127003)

Species Accession Gene Product
Brugia malayi Bm1_42845   Sodium/potassium-transporting ATPase alpha chain, putative
Brugia malayi Bm1_51740   Na,K-ATPase alpha subunit
Candida albicans CaO19.10084   similar to Pichia farinosa Acu1p, putative P-type ATPase involved in high affinity uptake of potassium or sodium (CAF22247)
Candida albicans CaO19.2552   similar to Pichia farinosa Acu1p, putative P-type ATPase involved in high affinity uptake of potassium or sodium (CAF22247)
Caenorhabditis elegans CELE_Y105E8A.12   Protein CATP-1, isoform A
Caenorhabditis elegans CELE_C09H5.2   Protein CATP-3, isoform B
Caenorhabditis elegans CELE_B0365.3   Protein EAT-6
Caenorhabditis elegans CELE_C01G12.8   Protein CATP-4
Caenorhabditis elegans CELE_C02E7.1   Protein CATP-2
Dictyostelium discoideum DDB_G0267924   Na+/K+ ATPase
Dictyostelium discoideum DDB_G0277269   ATPase, P-type cation exchange, alpha subunit
Drosophila melanogaster Dmel_CG45760   CG45760 gene product from transcript CG45760-RB
Drosophila melanogaster Dmel_CG5670   Na pump alpha subunit
Echinococcus granulosus EgrG_000342600   Na:K ATPase alpha subunit
Echinococcus multilocularis EmuJ_000342600   Na+:K+ ATPase alpha subunit
Giardia lamblia GL50803_96670   Potassium-transporting ATPase alpha chain 1
Homo sapiens ENSG00000132681   ATPase, Na+/K+ transporting, alpha 4 polypeptide
Homo sapiens ENSG00000075673   ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Homo sapiens ENSG00000018625   ATPase, Na+/K+ transporting, alpha 2 polypeptide
Homo sapiens ENSG00000105675   ATPase, H+/K+ exchanging, alpha polypeptide
Homo sapiens ENSG00000105409   ATPase, Na+/K+ transporting, alpha 3 polypeptide
Homo sapiens ENSG00000163399   ATPase, Na+/K+ transporting, alpha 1 polypeptide
Loa Loa (eye worm) LOAG_12371   hypothetical protein
Loa Loa (eye worm) LOAG_06053   sodium/potassium-transporting ATPase subunit alpha
Loa Loa (eye worm) LOAG_08751   hypothetical protein
Loa Loa (eye worm) LOAG_07482   hypothetical protein
Loa Loa (eye worm) LOAG_07650   Na,K-ATPase alpha subunit
Loa Loa (eye worm) LOAG_08750   hypothetical protein
Mycobacterium leprae ML2671   PROBABLE CATION-TRANSPORTER ATPASE I CTPI
Mus musculus ENSMUSG00000040907   ATPase, Na+/K+ transporting, alpha 3 polypeptide
Mus musculus ENSMUSG00000033161   ATPase, Na+/K+ transporting, alpha 1 polypeptide
Mus musculus ENSMUSG00000007097   ATPase, Na+/K+ transporting, alpha 2 polypeptide
Mus musculus ENSMUSG00000005553   ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Mus musculus ENSMUSG00000007107   ATPase, Na+/K+ transporting, alpha 4 polypeptide
Mus musculus ENSMUSG00000022229   ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Mycobacterium ulcerans MUL_1254   metal cation transporter p-type ATPase a
Onchocerca volvulus OVOC9796  
Schistosoma japonicum Sjp_0112320   Sodium/potassium-transporting ATPase subunit alpha, putative
Schistosoma japonicum Sjp_0108170   Sodium/potassium-transporting ATPase subunit alpha, putative
Schistosoma japonicum Sjp_0109810   Sodium/potassium-transporting ATPase subunit alpha-1 precursor, putative
Schistosoma japonicum Sjp_0016550   ko:K01538 Na+/K+-exchanging ATPase [EC3.6.3.9], putative
Schistosoma japonicum Sjp_0307290   Sodium/potassium-transporting ATPase subunit alpha, putative
Schistosoma japonicum Sjp_0016460   Sodium/potassium-transporting ATPase subunit alpha, putative
Schistosoma mansoni Smp_015020   Na+/K+ transporting ATPase subunit alpha
Schistosoma mansoni Smp_130300   na+/k+ atpase alpha subunit
Schmidtea mediterranea mk4.000996.10  
Schmidtea mediterranea mk4.000996.07   JYalpha
Schmidtea mediterranea mk4.000996.09  
Schmidtea mediterranea mk4.021250.00   Sodium/potassium-transporting ATPase subunit alpha
Schmidtea mediterranea mk4.007750.02  
Schmidtea mediterranea mk4.001001.04  
Schmidtea mediterranea mk4.000665.02  
Schmidtea mediterranea mk4.010072.00  
Schmidtea mediterranea mk4.019335.00   Sodium/potassium-transporting ATPase subunit alpha
Schmidtea mediterranea mk4.003370.00   Non-gastric H,K+-ATPase alpha subunit
Schmidtea mediterranea mk4.003370.02  
Schmidtea mediterranea mk4.001001.01   Sodium/potassium-transporting ATPase subunit alpha
Schmidtea mediterranea mk4.019335.02  
Schmidtea mediterranea mk4.019335.01  
Schmidtea mediterranea mk4.003370.01   JYalpha
Schmidtea mediterranea mk4.013441.00  
Schmidtea mediterranea mk4.000529.01  
Schmidtea mediterranea mk4.000996.11  

Essentiality

Sjp_0307290 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0365.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0365.3 Caenorhabditis elegans larval arrest wormbase
CELE_B0365.3 Caenorhabditis elegans slow growth wormbase
CELE_B0365.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Potassium-transporting ATPase alpha chain 1 Compounds References
Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide Compounds References
Homo sapiens ATPase, H+/K+ transporting, nongastric, alpha polypeptide Compounds References
Homo sapiens ATPase, Na+/K+ transporting, alpha 2 polypeptide Compounds References
Homo sapiens ATPase, Na+/K+ transporting, alpha 1 polypeptide Compounds References
Homo sapiens ATPase, H+/K+ exchanging, alpha polypeptide Compounds References
Rattus norvegicus Sodium/potassium-transporting ATPase alpha-1 chain Compounds References
Canis lupus familiaris Sodium/potassium-transporting ATPase alpha-1 chain Compounds References
Sus scrofa Sodium/potassium-transporting ATPase alpha-1 chain Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0307290 (Schistosoma japonicum), Sodium/potassium-transporting ATPase subunit alpha, putative
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